Chan Wai-Man, Lai Timothy Y Y, Tano Yasuo, Liu David T L, Li Kenneth K W, Lam Dennis S C
Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong Eye Hospital, Kowloon, Hong Kong, China.
Jpn J Ophthalmol. 2006 Mar-Apr;50(2):161-9. doi: 10.1007/s10384-005-0259-z.
We reviewed the indications, safety, and efficacy of photodynamic therapy with verteporfin in various macular diseases and vasculopathies, which are common in Asian populations, and compared the outcomes of photodynamic therapy in Asian patients with the outcomes in Caucasian patients.
Relevant clinical and laboratory original articles, case reports, and review articles that have been published in the literature between January 1999 and October 2004 were searched in Medline. The potential differences in the response to photodynamic therapy between Asian and Caucasian patients were evaluated. Articles in foreign languages with English abstracts were included.
Macular diseases commonly seen in Asian populations, including choroidal neovascularization (CNV) of age-related macular degeneration, secondary to pathologic myopia or from an idiopathic cause, and choroidal vasculopathies such as central serous chorioretinopathy and polypoidal choroidal vasculopathy were included in the review. The results were tabulated and the differences with Caucasian populations were compared and highlighted.
Photodynamic therapy has been found to be an effective and noninvasive treatment for various subfoveal CNV and choroidal vasculopathies of the macula. Diverse behavior in different ethnic groups is observed.
我们回顾了维替泊芬光动力疗法在各种黄斑疾病和血管病变中的适应症、安全性和疗效，这些疾病在亚洲人群中很常见，并比较了亚洲患者与白种人患者光动力疗法的治疗结果。
检索了1999年1月至2004年10月间发表在文献中的相关临床和实验室原创文章、病例报告及综述文章。评估了亚洲患者和白种人患者对光动力疗法反应的潜在差异。纳入了带有英文摘要的外语文章。
综述纳入了亚洲人群中常见的黄斑疾病，包括年龄相关性黄斑变性继发于病理性近视或特发性病因的脉络膜新生血管（CNV），以及脉络膜血管病变，如中心性浆液性脉络膜视网膜病变和息肉样脉络膜血管病变。结果列表呈现，并比较和突出了与白种人群体的差异。
已发现光动力疗法是治疗各种黄斑下CNV和黄斑脉络膜血管病变的一种有效且无创的治疗方法。观察到不同种族群体存在不同表现。
