Takahashi Y, Onoe T, Chiba T, Nakamura T, Hayashi Y, Hirose M, Wakuda K, Yamade I, Yamamoto Y, Ishiguro T
Department of Obstetrics and Gynecology, Shiga University of Medical Science.
Nihon Sanka Fujinka Gakkai Zasshi. 1991 Dec;43(12):1681-6.
Human papillomavirus (HPV) types 16, 18 and 33 were identified by means of the polymerase chain reaction using exfoliated cells from the uterine cervix in 361 patients. Of 261 patients without cervical lesions, 10(3.8%) patients had HPV DNA whereas 7(70.0%) of 10 patients with invasive cervical carcinomas had HPV DNA. The younger patients' group (29 year-old or less) without cervical lesions had a 6.5% HPV positive rate which was distinctly higher than the older patients' groups. No menopausal patient without cervical lesions had HPV DNA. In the cervical dysplasia group, the HPV DNA positive rate tended to be higher in the older patients. Type 16 was detected more often than types 18 or 33. However, the detectable incidence of type 16 in the follow up group was lower than in the cervical carcinoma groups. The younger patients without cervical lesions had a higher incidence of type 16 than the older patients. The younger patients with cervical neoplastic lesions had a lower incidence of type 16 than the older patients. These results suggest that type 16 has a higher frequency of cervical HPV infections than types 18 and 33. In addition, human papillomavirus is not the only causative factor in cervical carcinomas.
通过聚合酶链反应，利用361例患者子宫颈脱落细胞鉴定出16型、18型和33型人乳头瘤病毒（HPV）。在261例无宫颈病变的患者中，10例（3.8%）检测到HPV DNA，而在10例浸润性宫颈癌患者中，7例（70.0%）检测到HPV DNA。年龄较轻（29岁及以下）且无宫颈病变的患者组HPV阳性率为6.5%，明显高于年龄较大的患者组。无宫颈病变的绝经后患者未检测到HPV DNA。在宫颈发育异常组中，年龄较大患者的HPV DNA阳性率往往较高。检测到16型的频率高于18型或33型。然而，随访组中16型的可检测发生率低于宫颈癌组。年龄较轻且无宫颈病变的患者16型发生率高于年龄较大的患者。年龄较轻且有宫颈肿瘤性病变的患者16型发生率低于年龄较大的患者。这些结果表明，16型HPV感染宫颈的频率高于18型和33型。此外，人乳头瘤病毒并非宫颈癌的唯一致病因素。
