Suárez Alfonso, Valbuena Martha Cecilia, Rey Maritza, de Porras Quintana Luisa
Centro Dermatológico Federico Lleras Acosta, E.S.E. Bogota, Colombia.
Photodermatol Photoimmunol Photomed. 2006 Apr;22(2):55-8. doi: 10.1111/j.1600-0781.2006.00205.x.
Human leukocyte antigen (HLA) DRB1*0407 had been associated with actinic prurigo in different populations. This class II HLA-DR subtype had not been studied in Colombia.
The objective of this study was to establish whether there was an association of actinic prurigo with HLA DR in a Colombian population.
Forty patients with a clinical diagnosis of actinic prurigo and 40 healthy subjects, paired by age, sex and birthplace, were studied. HLA typing for HLA DRB1 and DRB1*04, if necessary, was performed by the PCR-SSP method using blood samples.
A high frequency of HLA DRB10407 was found in the patients (97.5% vs. 30%; P<0.00001). The allelic frequency of HLA DRB10407 was 63.8% in the case group, and 14.5% in the controls (P<0.00001). In the control group, there was a higher frequency of the alleles DRB101 (14.5% vs. 1.25%; P=0.0027) and DRB113 (23.7% vs. 2.5%; P=0.00013).
The small number of controls does not allow us to drive conclusions about other HLA alleles.
HLA subtype DRB10407, found in actinic prurigo patients in studies conducted in England, Scotland, Ireland and Mexico, was also associated in Colombian patients. This finding, concordant in patients from different ethnic groups, could be helpful in the diagnosis of this disease and probably important in its pathogenesis. DRB101 and DRB1*13 alleles were more frequent in controls than in patients; we do not know whether they play any role in the resistance to the disease.
人类白细胞抗原（HLA）DRB1*0407在不同人群中与光化性痒疹相关。在哥伦比亚尚未对这种II类HLA-DR亚型进行研究。
本研究的目的是确定在哥伦比亚人群中光化性痒疹与HLA DR是否存在关联。
研究了40例临床诊断为光化性痒疹的患者和40名健康受试者，根据年龄、性别和出生地进行配对。必要时，使用血液样本通过PCR-SSP方法对HLA DRB1和DRB1*04进行HLA分型。
在患者中发现HLA DRB10407的频率很高（97.5%对30%；P<0.00001）。HLA DRB10407的等位基因频率在病例组中为63.8%，在对照组中为14.5%（P<0.00001）。在对照组中，DRB101（14.5%对1.25%；P=0.0027）和DRB113（23.7%对2.5%；P=0.00013）等位基因的频率更高。
对照数量较少，无法就其他HLA等位基因得出结论。
在英国、苏格兰、爱尔兰和墨西哥进行的研究中，在光化性痒疹患者中发现的HLA亚型DRB10407在哥伦比亚患者中也存在关联。这一在不同种族患者中一致的发现可能有助于该疾病的诊断，并且可能在其发病机制中具有重要意义。DRB101和DRB1*13等位基因在对照组中的频率高于患者组；我们不知道它们是否在疾病抵抗中起任何作用。
