Tato Cristina M, Laurence Arian, O'Shea John J
Molecular Immunology and Inflammation Branch, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
J Exp Med. 2006 Apr 17;203(4):809-12. doi: 10.1084/jem.20060522. Epub 2006 Apr 10.
In the dark ages of T cell biology, we considered two fates for differentiated CD4+ T cells: T helper (Th)1 and Th2 cells. Now we know that the reality is much more complex and interesting. The newest Th cell subset produces the cytokine IL-17. New evidence shows that the IL-17-related cytokine IL-25 is essential for Th2 responses in two infectious disease models.
在T细胞生物学的黑暗时代，我们认为分化的CD4+ T细胞有两种命运：辅助性T（Th）1细胞和Th2细胞。现在我们知道，实际情况要复杂和有趣得多。最新的Th细胞亚群会产生细胞因子白细胞介素-17（IL-17）。新证据表明，在两种传染病模型中，与IL-17相关的细胞因子IL-25对Th2反应至关重要。
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