Rydholm Carla, Szakacs George, Lutzoni François
Biology Department, Duke University, Box 90338, Durham, NC 27708, USA.
Eukaryot Cell. 2006 Apr;5(4):650-7. doi: 10.1128/EC.5.4.650-657.2006.
Aspergillus fumigatus is an anamorphic euascomycete mold with a ubiquitous presence worldwide. Despite intensive work to understand its success as a pathogen infecting immunosuppressed patients, the population dynamics and recent evolutionary history of A. fumigatus remain understudied. We examined patterns of genetic variation at three intergenic loci for 70 natural isolates from Europe, North America, South America, Asia, Africa, and Australia. The same loci were used to analyze within-population genetic variation for 33 isolates obtained from five geographic locations. Neither data set detected evidence of population differentiation or found any association between the genetic and geographic distances among these isolates. No evidence for genetic differentiation within the two A. fumigatus mating types was detected. The genetic diversity of A. fumigatus, contrasted with that of its close teleomorphic relatives, Neosartorya fischeri and Neosartorya spinosa, is remarkably low.
烟曲霉是一种无性型真子囊菌霉菌，在全球广泛存在。尽管人们为了解其作为感染免疫抑制患者的病原体的成功机制进行了大量研究，但烟曲霉的种群动态和近期进化历史仍未得到充分研究。我们检测了来自欧洲、北美、南美、亚洲、非洲和澳大利亚的70株自然分离株在三个基因间隔区的遗传变异模式。使用相同的基因座分析了从五个地理位置获得的33株分离株的种群内遗传变异。两个数据集均未检测到种群分化的证据，也未发现这些分离株的遗传距离与地理距离之间存在任何关联。在两种烟曲霉交配型中均未检测到遗传分化的证据。与其近缘有性型亲属费氏新萨托菌和棘孢新萨托菌相比，烟曲霉的遗传多样性非常低。
