混合性冷球蛋白血症患者体内的丙型肝炎病毒抗体

Antibodies to hepatitis C virus in patients with mixed cryoglobulinemia.

作者信息

Ferri C, Greco F, Longombardo G, Palla P, Moretti A, Marzo E, Fosella P V, Pasero G, Bombardieri S

机构信息

Rheumatology Unit, University of Pisa, Italy.

出版信息

Arthritis Rheum. 1991 Dec;34(12):1606-10. doi: 10.1002/art.1780341221.

DOI:10.1002/art.1780341221

PMID:1660716

Abstract

The prevalence of antibodies to hepatitis C virus (HCVAb) was investigated in 52 unselected patients with mixed cryoglobulinemia and in 84 patients with other systemic immunologic diseases. HCVAb were detected by an enzyme-linked immunosorbent assay, and their specificity was evaluated by a recombinant-based immunoblot assay. The presence of HBV-related markers was investigated in the same samples. HCVAb were found in 54% of mixed cryoglobulinemia patients, and the finding was confirmed by recombinant-based immunoblot assay in all cases. HCVAb and/or HBV markers were present in 70% of the patients. HCVAb seropositivity was significantly more frequent in mixed cryoglobulinemia patients with biopsy-proven liver involvement (P less than 0.01) and with increased serum transaminase levels (P less than 0.01). HCVAb were virtually absent in control patients with other immunologic diseases. These results support the notion that viral agents, i.e., HCV and possibly HBV, have a role in the pathogenesis of mixed cryoglobulinemia patients.

摘要

对52例未经挑选的混合性冷球蛋白血症患者以及84例患有其他系统性免疫疾病的患者进行了丙型肝炎病毒抗体（HCVAb）的患病率调查。采用酶联免疫吸附测定法检测HCVAb，并通过基于重组体的免疫印迹测定法评估其特异性。在相同样本中调查了与HBV相关标志物的存在情况。在54%的混合性冷球蛋白血症患者中发现了HCVAb，所有病例均通过基于重组体的免疫印迹测定法证实了这一发现。70%的患者存在HCVAb和/或HBV标志物。在经活检证实有肝脏受累（P<0.01）以及血清转氨酶水平升高（P<0.01）的混合性冷球蛋白血症患者中，HCVAb血清阳性更为常见。在患有其他免疫疾病的对照患者中几乎未检测到HCVAb。这些结果支持病毒因子，即HCV以及可能的HBV，在混合性冷球蛋白血症患者发病机制中起作用这一观点。