Cabral A M, Vasquez E C
Department of Physiological Sciences, Biomedical Center, UFES, Vitória, Espirito Santo, Brazil.
Am J Hypertens. 1991 Oct;4(10 Pt 1):815-9. doi: 10.1093/ajh/4.10.815.
The present study has examined the time course of autonomic tone changes in two-kidney, one-clip (2K1C) and one-kidney, one-clip (1K1C) renal hypertension. In conscious rats, cardiac sympathetic and vagal tone were determined using propranolol and atropine, respectively. The development of renovascular hypertension was accompanied by a significant tachycardia, increase in cardiac sympathetic tone and decrease in cardiac vagal tone. In the isolated perfused heart we observed a reduced chronotropic response to isoproterenol. These alterations were transitory in 2K1C and greater and more persistent in 1K1C renal hypertension. These results show the relative role played by the cardiac sympathetic and vagal systems in the maintenance of tachycardia in renovascular hypertension.
本研究检测了二肾一夹（2K1C）和一肾一夹（1K1C）肾性高血压中自主神经张力变化的时间进程。在清醒大鼠中，分别使用普萘洛尔和阿托品测定心脏交感神经和迷走神经张力。肾血管性高血压的发展伴随着显著的心动过速、心脏交感神经张力增加和心脏迷走神经张力降低。在离体灌注心脏中，我们观察到对异丙肾上腺素的变时反应减弱。这些改变在2K1C中是短暂的，而在1K1C肾性高血压中则更显著且持续时间更长。这些结果显示了心脏交感神经和迷走神经系统在肾血管性高血压心动过速维持中所起的相对作用。
