Prescrire Int. 2006 Apr;15(82):62-3.
(1) Short-term clinical trials have shown that soy phytoestrogens have a slight preventive effect on hot flushes. However, this finding is based on a low level of evidence. (2) A double-blind placebo-controlled trial involving about 300 women and lasting 5 years showed that phytoestrogens were associated with an increase in the incidence of endometrial hyperplasia (3.8% versus 0%). (3) In practice, the risk-benefit ratio of phytoestrogens has not been adequately assessed. Their effect on the endometrium, and the many unknowns concerning the risk of thromboembolism and breast cancer, may offset the modest effect of phytoestrogens on hot flushes.
(1) 短期临床试验表明，大豆植物雌激素对潮热有轻微预防作用。然而，这一发现证据水平较低。(2) 一项涉及约300名女性、为期5年的双盲安慰剂对照试验表明，植物雌激素与子宫内膜增生发病率增加有关（3.8% 对0%）。(3) 在实际应用中，植物雌激素的风险效益比尚未得到充分评估。它们对子宫内膜的影响，以及关于血栓栓塞和乳腺癌风险的诸多未知因素，可能会抵消植物雌激素对潮热的适度作用。
