• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

A mixed-valent ruthenium-oxo oxalato cluster Na7[Ru4(mu3-O)4(C2O4)6] with potent anti-HIV activities.

作者信息

Wong Ella Lai-Ming, Sun Raymond Wai-Yin, Chung Nancy P-Y, Lin Chen-Lung Steve, Zhu Nianyong, Che Chi-Ming

机构信息

Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.

出版信息

J Am Chem Soc. 2006 Apr 19;128(15):4938-9. doi: 10.1021/ja057883k.

DOI:10.1021/ja057883k
PMID:16608312
Abstract

A structurally characterized mixed-valent tetranuclear ruthenium-oxo oxalato cluster exhibits anti-viral activities toward R5- and X4-tropic HIV-1, and possesses cytoprotective activity toward HIV-1 infected cells.

摘要

相似文献

1
A mixed-valent ruthenium-oxo oxalato cluster Na7[Ru4(mu3-O)4(C2O4)6] with potent anti-HIV activities.
J Am Chem Soc. 2006 Apr 19;128(15):4938-9. doi: 10.1021/ja057883k.
2
[Anti-HIV-1 effect of compound K3 from flower of Japanese pagoda tree in vitro].[国槐花朵中化合物K3的体外抗HIV-1作用]
Zhong Yao Cai. 2006 Apr;29(4):355-8.
3
Non-nucleoside HIV-1 reverse-transcriptase inhibitors. Part 10. Synthesis and anti-HIV activity of 5-alkyl-6-(1-naphthylmethyl)pyrimidin-4(3H)-ones with a mono- or disubstituted 2-amino function as novel 'dihydro-alkoxy-benzyl-oxopyrimidine' (DABO) analogues.非核苷类HIV-1逆转录酶抑制剂。第10部分。具有单取代或双取代2-氨基功能的5-烷基-6-(1-萘甲基)嘧啶-4(3H)-酮作为新型“二氢烷氧基苄基氧嘧啶”(DABO)类似物的合成及抗HIV活性
Chem Biodivers. 2008 Jan;5(1):168-76. doi: 10.1002/cbdv.200890008.
4
Synthesis and evaluation of N-aryl pyrrolidinones as novel anti-HIV-1 agents. Part 1.新型抗HIV-1药物N-芳基吡咯烷酮的合成与评价。第1部分。
Bioorg Med Chem Lett. 2006 Jul 1;16(13):3430-3. doi: 10.1016/j.bmcl.2006.04.012. Epub 2006 Apr 24.
5
A novel heme-containing protein with anti-HIV-1 activity from skin secretions of Bufo andrewsi.一种来自华西蟾蜍皮肤分泌物的具有抗HIV-1活性的新型含血红素蛋白。
Toxicon. 2005 Nov;46(6):619-24. doi: 10.1016/j.toxicon.2005.06.022. Epub 2005 Sep 12.
6
Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase--structure-activity relationships and crystallographic analysis.作为HIV-1逆转录酶非核苷抑制剂的三唑衍生物——构效关系及晶体学分析
Bioorg Med Chem Lett. 2008 Feb 1;18(3):1131-4. doi: 10.1016/j.bmcl.2007.11.127. Epub 2007 Dec 5.
7
New pyridinone derivatives as potent HIV-1 nonnucleoside reverse transcriptase inhibitors.新型吡啶酮衍生物作为强效HIV-1非核苷类逆转录酶抑制剂
J Med Chem. 2009 Jun 25;52(12):3636-43. doi: 10.1021/jm801438e.
8
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.取代四氢喹啉作为逆转录酶及其关键突变体的强效变构抑制剂。
Bioorg Med Chem Lett. 2009 Sep 1;19(17):5119-23. doi: 10.1016/j.bmcl.2009.07.031. Epub 2009 Jul 10.
9
Therapeutic strategies towards HIV-1 infection in macrophages.针对巨噬细胞中HIV-1感染的治疗策略。
Antiviral Res. 2006 Sep;71(2-3):293-300. doi: 10.1016/j.antiviral.2006.05.015. Epub 2006 Jun 9.
10
Design and synthesis of 2-(2,6-dibromophenyl)-3-heteroaryl-1,3-thiazolidin-4-ones as anti-HIV agents.作为抗HIV药物的2-(2,6-二溴苯基)-3-杂芳基-1,3-噻唑烷-4-酮的设计与合成
Eur J Med Chem. 2008 Dec;43(12):2800-6. doi: 10.1016/j.ejmech.2007.12.015. Epub 2007 Dec 27.

引用本文的文献

1
Complexes of Ruthenium(II) as Promising Dual-Active Agents against Cancer and Viral Infections.钌(II)配合物作为对抗癌症和病毒感染的有前景的双活性药物。
Pharmaceuticals (Basel). 2023 Dec 15;16(12):1729. doi: 10.3390/ph16121729.
2
Discrete, Cationic Palladium(II)-Oxo Clusters via f-Metal Ion Incorporation and their Macrocyclic Host-Guest Interactions with Sulfonatocalixarenes.通过 f 族金属离子掺入合成离散的、阳离子型钯(II)-氧簇合物及其与磺化杯芳烃的大环主体-客体相互作用。
Angew Chem Int Ed Engl. 2022 Jun 20;61(25):e202203114. doi: 10.1002/anie.202203114. Epub 2022 Apr 27.
3
Metallodrug Profiling against SARS-CoV-2 Target Proteins Identifies Highly Potent Inhibitors of the S/ACE2 interaction and the Papain-like Protease PL.
针对 SARS-CoV-2 靶标蛋白的金属药物分析鉴定出 S/ACE2 相互作用和木瓜蛋白酶样蛋白酶 PL 的强效抑制剂。
Chemistry. 2021 Dec 20;27(71):17928-17940. doi: 10.1002/chem.202103258. Epub 2021 Nov 23.
4
Ruthenium Complexes in the Fight against Pathogenic Microorganisms. An Extensive Review.用于对抗病原微生物的钌配合物。全面综述。
Pharmaceutics. 2021 Jun 13;13(6):874. doi: 10.3390/pharmaceutics13060874.
5
Expanding medicinal chemistry into 3D space: metallofragments as 3D scaffolds for fragment-based drug discovery.将药物化学扩展到三维空间:金属片段作为基于片段药物发现的三维支架
Chem Sci. 2019 Dec 12;11(5):1216-1225. doi: 10.1039/c9sc05586j.
6
Discovery and Supramolecular Interactions of Neutral Palladium-Oxo Clusters Pd and Pd.中性钯-氧簇合物Pd和Pd的发现及超分子相互作用
Angew Chem Int Ed Engl. 2021 Feb 15;60(7):3632-3639. doi: 10.1002/anie.202010690. Epub 2020 Dec 15.
7
Degradable Organically-Derivatized Polyoxometalate with Enhanced Activity against Glioblastoma Cell Line.
Sci Rep. 2016 Sep 23;6:33529. doi: 10.1038/srep33529.