Lorenzi M, Gerich J E, Karam J H, Forsham P H
J Clin Endocrinol Metab. 1975 Jun;40(6):1121-4. doi: 10.1210/jcem-40-6-1121.
The effects of somatostatin on tolbutamide-stimulated insulin release were studied in 4 patients with insulin-producing tumors of the pancreas and in 6 normal subjects. In contrast to its effective inhibition of insulin release in normal subjects, somatostatin, without exception, failed to inhibit tolbutamide-induced insulin release in the patients with pancreatic beta-cell tumors. This differential effect of somatostatin may prove useful in the diagnosis of insulin-producing tumors of the pancreas.
在4例胰腺胰岛素瘤患者和6名正常受试者中研究了生长抑素对甲苯磺丁脲刺激的胰岛素释放的影响。与它对正常受试者胰岛素释放的有效抑制作用相反，生长抑素无一例外地未能抑制胰腺β细胞瘤患者中甲苯磺丁脲诱导的胰岛素释放。生长抑素的这种差异效应可能对胰腺胰岛素瘤的诊断有用。
