Firat Fatih, Cermik Tevfik F, Sarikaya Ali, Berkarda Sakir
Hospital of the University of Trakya, Turkey.
Nucl Med Commun. 2006 May;27(5):447-53. doi: 10.1097/00006231-200605000-00006.
To assess the effect of gender and age on [99mTc]pertechnetate salivary gland scintigraphy (SGS) in healthy subjects.
The study population consisted of 93 normal subjects (46 women, 47 men; age range 20-59 years). The subjects were categorized into eight (four female and four male) subgroups according to age decades. Dynamic SGS was performed after intravenous injection of 370 MBq [99mTc]pertechnetate. Anterior salivary gland images were acquired for 30 min. On the basis of the time-activity curves, three functional parameters were calculated for the parotid and submandibular salivary glands: (1) the first minute uptake ratio, (2) the maximum uptake ratio, and (3) the maximum secretion percentage.
For women, all parotid and submandibular functional parameters had a peak in the fourth decade group. The comparison of four age groups in the female subjects showed significant differences, except for the third versus the fifth decades, at least for one parameter. The number of significant differences was highest in the comparison between the second versus the fourth decades. Among men, the highest values for all parotid and submandibular parameters were in the second decade, except for the first minute uptake ratio in the submandibular gland. The number of parameters that were significantly different among the four age groups in men was lower than in women. The first minute uptake ratio of the submandibular gland had the most significant differences among the groups of male subjects.
Age and gender differences have a significant effect on salivary gland functions which is more apparent in women than in men.
评估性别和年龄对健康受试者唾液腺[99mTc]高锝酸盐闪烁扫描术（SGS）的影响。
研究对象包括93名正常受试者（46名女性，47名男性；年龄范围20 - 59岁）。根据年龄十年分组，将受试者分为八个亚组（四个女性亚组和四个男性亚组）。静脉注射370 MBq[99mTc]高锝酸盐后进行动态SGS。采集唾液腺前位图像30分钟。根据时间 - 活性曲线，计算腮腺和颌下腺的三个功能参数：（1）第一分钟摄取率，（2）最大摄取率，（3）最大分泌百分比。
对于女性，所有腮腺和颌下腺功能参数在第四个十年组达到峰值。女性受试者四个年龄组的比较显示，除了第三个十年与第五个十年外，至少有一个参数存在显著差异。第二和第四个十年组之间的显著差异数量最多。在男性中，除颌下腺的第一分钟摄取率外，所有腮腺和颌下腺参数的最高值出现在第二个十年。男性四个年龄组之间存在显著差异的参数数量低于女性。颌下腺的第一分钟摄取率在男性受试者组之间的差异最为显著。
年龄和性别差异对唾液腺功能有显著影响，在女性中比在男性中更明显。
