Leroux P, de Champs Léger H, Le Vezouet C-A, Ilie D, Regnier C, Motlagh P, Soulie J-H, Perles C, Gilbert J-C, Safar M, Blacher J
Centre de Diagnostic, Hôtel-Dieu, AP-HP, 4 Place du Parvis Notre-Dame, 75181 Paris cedex 04.
J Mal Vasc. 2006 Feb;31(1):43-5. doi: 10.1016/s0398-0499(06)76516-7.
Thrombocytopenia within the context of disseminated tuberculosis can lead to complications requiring rapid treatment. Although the origin is generally central, thrombocytopenia can arise from an immune disorder. We hereby report a case of disseminated tuberculosis associated with thrombocytopenia, which required, in addition to antituberculosis therapy initiated before bacteriological proof, corticosteroid treatment and multiple platelet transfusions. The discovery of anti-platelet antibodies along with the success of immunomodulator therapy confirmed the auto-immune origin of this thrombocytopenia.