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大动脉炎合并活动性肺结核:1 例儿科病例。

Takayasu arteritis presenting in the context of active tuberculosis: a pediatric case.

机构信息

Pediatric Rheumatology, Hospital for Special Surgery, NY Weill Cornell Medical Center, New York, NY, USA.

出版信息

J Clin Rheumatol. 2013 Sep;19(6):344-7. doi: 10.1097/RHU.0b013e31829ce750.

Abstract

Takayasu arteritis (TA) is a large-vessel vasculitis, most commonly presenting in young adults and more rarely in pediatric patients. An apparent association between TA and Mycobacterium tuberculosis has been noted previously, although this potential relationship is not yet understood. We present the case of a 16-year-old Haitian girl diagnosed with TA, originally presenting in the context of active tuberculosis. Our patient has been treated with antituberculosis therapy, corticosteroids, methotrexate, and rituximab to control her continued active vasculitis. With this case report, we seek to promote further exploration of the apparent association between TA and tuberculosis, as further clarification of the nature of this relationship may lead to the development of more targeted therapies and better outcomes for TA patients.

摘要

Takayasu 动脉炎(TA)是一种大血管炎,最常见于年轻成年人,在儿科患者中较少见。先前已经注意到 TA 与结核分枝杆菌之间存在明显的关联,尽管这种潜在的关系尚不清楚。我们报告了一例 16 岁的海地女孩被诊断为 TA 的病例,最初是在活动性肺结核的背景下出现的。我们的患者已接受抗结核治疗、皮质类固醇、甲氨蝶呤和利妥昔单抗治疗,以控制她持续的活动性血管炎。通过本病例报告,我们旨在进一步探讨 TA 与结核病之间的明显关联,因为进一步阐明这种关系的性质可能会导致为 TA 患者开发更有针对性的治疗方法和更好的治疗结果。

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