Roilides E, Marshall D, Venzon D, Butler K, Husson R, Pizzo P A
Infectious Diseases Section, National Cancer Institute, Bethesda, MD 20892.
Pediatr Infect Dis J. 1991 Nov;10(11):813-9. doi: 10.1097/00006454-199111000-00004.
We conducted a retrospective study to analyze the impact of central venous catheters (CVCs) and antiretroviral therapy on the frequency and the patterns of bacterial infections in children infected with human immunodeficiency virus during a 3-year period. Among 204 bacterial infections other than otitis media reviewed, soft tissue infection (n = 69), bacteremia (n = 57), pneumonia (n = 27) and sinusitis (n = 27) were encountered most frequently. Catheter-related staphylococcal infection was the most common infection in children with CVCs, particularly in those who were less than 6 years old. In children without CVCs, Streptococcus pneumoniae was the most frequent organism. Younger children had more CVC-related infections whereas children with lower CD4 counts had more CVC-related and CVC-unrelated infections. A lower frequency of CVC-unrelated infections was detected in patients who received antiretroviral therapy, especially those receiving a continuous infusion of zidovudine. These data suggest that increased frequency and altered patterns of bacterial infections are associated with the use of CVCs in these patients, but antiretroviral therapy may reduce the frequency of CVC-unrelated infections.
我们进行了一项回顾性研究，以分析中心静脉导管（CVC）和抗逆转录病毒疗法对感染人类免疫缺陷病毒的儿童在3年期间细菌感染的频率和模式的影响。在回顾的204例非中耳炎细菌感染中，最常遇到的是软组织感染（n = 69）、菌血症（n = 57）、肺炎（n = 27）和鼻窦炎（n = 27）。导管相关的葡萄球菌感染是有CVC的儿童中最常见的感染，尤其是在6岁以下的儿童中。在没有CVC的儿童中，肺炎链球菌是最常见的病原体。年龄较小的儿童有更多与CVC相关的感染，而CD4计数较低的儿童有更多与CVC相关和与CVC无关的感染。在接受抗逆转录病毒疗法的患者中，尤其是接受齐多夫定持续输注的患者中，检测到与CVC无关的感染频率较低。这些数据表明，细菌感染频率的增加和模式的改变与这些患者使用CVC有关，但抗逆转录病毒疗法可能会降低与CVC无关的感染频率。
