Vermeulen Linda, Vanden Berghe Wim, Haegeman Guy
Laboratory for Eukaryotic Gene Expression and Signal Transduction (LEGEST), Department of Molecular Biology, Ghent University, K. L. Ledeganckstraat 35, 9000 Gent, Belgium.
Cancer Treat Res. 2006;130:89-102.
Nuclear factor kappaB (NF-kappaB) is regarded as a key regulator of inflammation; hence, several inflammatory diseases result from deregulation of NF-kappaB signaling. There is, however, also increasing evidence for a preponderant role of NF-kappaB in tumor development and progression. Constitutive activation of NF-kappaB activity by signaling defects, mutations or chromosomal rearrangements can be found in a wide variety of cancers. Additionally, a causal link between inflammation and cancer has been noted, which makes NF-kappaB an interesting target for development of both anti-inflammatory and anti-cancer therapeutics. Here, we review current knowledge of NF-kappaB signal transduction, focusing on the regulation of its transcriptional activity by post-translational modification of the NF-kappaB subunits.
核因子κB（NF-κB）被视为炎症的关键调节因子；因此，多种炎症性疾病是由NF-κB信号传导失调所致。然而，也有越来越多的证据表明NF-κB在肿瘤发生和发展中起主要作用。在多种癌症中都可发现，由于信号缺陷、突变或染色体重排导致NF-κB活性的组成性激活。此外，炎症与癌症之间的因果联系也已得到证实，这使得NF-κB成为开发抗炎和抗癌治疗药物的一个有趣靶点。在此，我们综述了目前关于NF-κB信号转导的知识，重点关注通过NF-κB亚基的翻译后修饰对其转录活性的调节。
