Yorgason Joshua G, Fayad Jose N, Kalinec Federico
Gonda Department of Cell and Molecular Biology, House Ear Institute, Los Angeles, CA 90057, USA.
Expert Opin Drug Saf. 2006 May;5(3):383-99. doi: 10.1517/14740338.5.3.383.
Ototoxicity is a trait shared by aminoglycoside and macrolide antibiotics, loop diuretics, platinum-based chemotherapeutic agents, some NSAIDs and antimalarial medications. Because their benefits in combating certain life-threatening diseases often outweigh the risks, the use of these ototoxic drugs cannot simply be avoided. In this review, the authors discuss some of the most frequently used ototoxic drugs and what is currently known about the cell and molecular mechanisms underlying their noxious effects. The authors also provide suggestions for the clinical management of ototoxic medications, including ototoxic detection and drug monitoring. Understanding the mechanisms of drug ototoxicity may lead to new strategies for preventing and curing drug-induced hearing loss, as well as developing new pharmacological drugs with less toxic side effects.
耳毒性是氨基糖苷类和大环内酯类抗生素、袢利尿剂、铂类化疗药物、某些非甾体抗炎药和抗疟药物共有的一种特性。由于它们在对抗某些危及生命的疾病方面的益处往往超过风险，因此不能简单地避免使用这些耳毒性药物。在这篇综述中，作者讨论了一些最常用的耳毒性药物以及目前已知的其有害作用的细胞和分子机制。作者还提供了耳毒性药物临床管理的建议，包括耳毒性检测和药物监测。了解药物耳毒性的机制可能会带来预防和治疗药物性听力损失的新策略，以及开发毒性副作用较小的新药。
