Heese Klaus, Akatsu Hiroyasu
Department of Molecular and Cell Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
Curr Alzheimer Res. 2006 Apr;3(2):109-21. doi: 10.2174/156720506776383022.
Alzheimer's disease (AD) is an age-related neurodegenerative disorder that is characterized by a progressive loss in memory and deterioration of the higher cognitive functions. The brain of an individual with AD exhibits extracellular senile plaques of aggregated amyloid-beta-peptide (Abeta), intracellular neurofibrillary tangles (NFTs) that consist of hyperphosphorylated tau protein (P-tau) and a profound loss of basal forebrain cholinergic neurons that innervate the hippocampus and the neocortex. Recent data obtained via genomics, proteomics and molecular genetics, have gleaned new information with regard to the physiological and pathophysiological functions of the amyloid precursor protein (APP) and its cleavage product Abeta. This review glances over several aspects that may play a major role in the pathogenesis of AD providing an insight into APP's and Abeta's interplay with other cellular systems.
阿尔茨海默病（AD）是一种与年龄相关的神经退行性疾病，其特征是记忆力逐渐丧失和高级认知功能退化。患有AD的个体大脑表现出由聚集的β-淀粉样肽（Aβ）形成的细胞外老年斑、由高度磷酸化的tau蛋白（P-tau）组成的细胞内神经原纤维缠结（NFTs），以及支配海马体和新皮质的基底前脑胆碱能神经元的大量丧失。通过基因组学、蛋白质组学和分子遗传学获得的最新数据，已经收集到了关于淀粉样前体蛋白（APP）及其裂解产物Aβ的生理和病理生理功能的新信息。本综述浏览了可能在AD发病机制中起主要作用的几个方面，深入了解了APP和Aβ与其他细胞系统的相互作用。
