Nyholt Dale R
Queensland Institute of Medical Research, Brisbane, Australia.
Twin Res Hum Genet. 2006 Apr;9(2):194-7. doi: 10.1375/183242706776382383.
Accurate determination of same-sex twin zygosity is important for medical, scientific and personal reasons. Determination may be based upon questionnaire data, blood group, enzyme isoforms and fetal membrane examination, but assignment of zygosity must ultimately be confirmed by genotypic data. Here methods are reviewed for calculating average probabilities of correctly concluding a twin pair is monozygotic, given they share the same genotypes across all loci for commonly utilized multiplex short tandem repeat (STR) kits. Numerous tools enabling convenient and accurate zygosity probability calculation may be accessed via the ZygProb homepage at http://genepi.qimr.edu.au/general/daleN/ZygProb/
出于医学、科学和个人原因，准确确定同性双胞胎的合子性很重要。确定可以基于问卷数据、血型、酶同工型和胎膜检查，但合子性的判定最终必须通过基因型数据来确认。本文综述了一些方法，这些方法用于计算在常用的多重短串联重复序列（STR）试剂盒中，双胞胎对在所有位点共享相同基因型的情况下，正确判定其为同卵双胞胎的平均概率。通过ZygProb主页（http://genepi.qimr.edu.au/general/daleN/ZygProb/）可以访问许多能够方便、准确地计算合子性概率的工具。
