Fejer René, Hartvigsen Jan, Kyvik Kirsten Ohm
Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.
Twin Res Hum Genet. 2006 Apr;9(2):198-204. doi: 10.1375/183242706776382482.
Experimental studies have suggested biological factors as a possible explanation for gender disparities in perception of pain. Recently, heritability of liability to neck pain (NP) has been found to be statistically significantly larger in women compared to men. However, no studies have been conducted to determine whether the sex differences in heritability of NP are due to sex-specific genetic factors. Data on lifetime prevalence of NP from a population-based cross-sectional survey of 33,794 Danish twins were collected and age-stratified univariate biometrical modeling using sex-limitation models was performed based on 10,605 dizygotic (DZ) twins of opposite sex to estimate the qualitative sex differences. In a full sex-limitation model the genetic component in females were higher than in males, but the genetic and the shared environmental correlations were equal to what is normally assumed between same-sex DZ twins. A 'no-sex-effects' model showed the overall best model fit which confirms absence of sex-related gene interaction. The age-stratified sex-limitation models showed similar results. Thus, there is no evidence for a sex-specific genetic influence in the liability of heritability of NP.
实验研究表明，生物因素可能是疼痛感知中性别差异的一种解释。最近发现，与男性相比，女性颈部疼痛（NP）易感性的遗传力在统计学上显著更高。然而，尚未进行研究来确定NP遗传力的性别差异是否归因于性别特异性遗传因素。收集了基于人群的33794名丹麦双胞胎横断面调查中NP终生患病率的数据，并基于10605对异性双卵（DZ）双胞胎，使用性别限制模型进行年龄分层单变量生物统计学建模，以估计定性性别差异。在一个完全性别限制模型中，女性的遗传成分高于男性，但遗传和共同环境相关性与同性DZ双胞胎之间通常假设的情况相同。一个“无性别效应”模型显示出总体最佳的模型拟合，这证实了不存在与性别相关的基因相互作用。年龄分层性别限制模型显示了相似的结果。因此，没有证据表明NP遗传力易感性存在性别特异性遗传影响。
