Pontisso P, Basso G, Perilongo G, Morsica G, Cecchetto G, Ruvoletto M G, Alberti A
Istituto di Medicina Clinica, Università di Padova, Italy.
Cancer Detect Prev. 1991;15(5):363-8.
Hepatitis B virus (HBV) infection was evaluated in serum and liver specimens of eight Italian children with primary liver cancer. All children were negative for HBV markers in serum but four of them showed HBV-DNA sequences and/or HBs antigen expression in the liver. In one case, viral DNA was present in both neoplastic and non-neoplastic tissue, while in one case HBV-DNA was detectable only in nontumoral tissue and in one case only in the tumor area. In these cases, scattered HBsAg was expressed in the cytoplasm of cells in normal part of the liver and in another case neoplastic cells secreted HBsAg in culture. In two cases, the histologic diagnosis was HCC; one case had mixed HPB and one had macrotrabecular HPB. All children were more than 1 year of age. The remaining four children were histologically diagnosed as HPB and were less than 1 year of age. These findings suggest that HBV may be a cofactor for the development of liver cancer also in children of Western countries and that the risk of infection progressively increases with age.
对8名患有原发性肝癌的意大利儿童的血清和肝脏标本进行了乙型肝炎病毒（HBV）感染评估。所有儿童血清中的HBV标志物均为阴性，但其中4名儿童的肝脏中显示出HBV-DNA序列和/或HBs抗原表达。在1例中，肿瘤组织和非肿瘤组织中均存在病毒DNA，而在1例中仅在非肿瘤组织中可检测到HBV-DNA，在1例中仅在肿瘤区域可检测到。在这些病例中，肝脏正常部位的细胞胞质中散在表达HBsAg，在另1例中肿瘤细胞在培养中分泌HBsAg。2例的组织学诊断为肝细胞癌（HCC）；1例为混合型肝细胞癌（HPB），1例为大小梁型HPB。所有儿童年龄均超过1岁。其余4名儿童经组织学诊断为HPB，年龄小于1岁。这些发现表明，在西方国家儿童中，HBV可能也是肝癌发生的一个辅助因素，且感染风险随年龄增长而逐渐增加。
