癌症与妊娠具有相似的免疫逃逸机制。
Cancer and pregnancy share similar mechanisms of immunological escape.
作者信息
Wilczyński Jacek R
机构信息
Department of Gynecological Surgery, Polish Mother's Health Center Research Institute, Medical University, Lodz, Poland.
出版信息
Chemotherapy. 2006;52(3):107-10. doi: 10.1159/000092537. Epub 2006 Apr 4.
BACKGROUND
Despite the fact that trophoblasts and cancer are both immunogenic, they are able to escape from host immunosurveillance, and the precise mechanisms involved in this process are surprisingly similar in both situations.
METHODS
A literature review of studies on immunological changes occurring during normal pregnancy and cancer was performed.
RESULTS
Loss or downregulation of classical HLA antigens as well as the presence of non-classical HLA-G molecules, a Th2 cytokine activity shift, secretion of immunosuppressive factors and blocking antibodies and finally induction of apoptosis in immunocytes seem to be the most effective mechanisms of immunological escape in pregnancy and cancer.
CONCLUSIONS
The process of immunological escape in cancer and pregnancy is based on similar mechanisms.
背景
尽管滋养层细胞和癌细胞都具有免疫原性，但它们都能够逃避宿主的免疫监视，并且在这两种情况下，参与该过程的精确机制惊人地相似。
方法
对正常妊娠和癌症期间发生的免疫变化的研究进行文献综述。
结果
经典HLA抗原的缺失或下调以及非经典HLA-G分子的存在、Th2细胞因子活性的转变、免疫抑制因子和封闭抗体的分泌，以及最终免疫细胞凋亡的诱导，似乎是妊娠和癌症中免疫逃逸的最有效机制。
结论
癌症和妊娠中的免疫逃逸过程基于相似的机制。
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