Nagata Yasushi, Takayama Kenji, Matsuo Yukinori, Norihisa Yoshiki, Mizowaki Takashi, Sakamoto Masato, Yano Shinsuke, Narita Yuichiro, Yamamoto Tokihiro, Hiraoka Masahiro
Dept. of Radiation Oncology, Kyoto University Graduate School of Medicine.
Gan To Kagaku Ryoho. 2006 Apr;33(4):455-61.
The techniques of three-dimensional conformal radiotherapy (3 D-CRT) and patient immobilization have recently been developed, enabling us to focus high doses on the target with relatively less irradiation of normal tissues. In radiotherapy for solitary lung tumors, the local control may be safely improved by delivering a higher dose at only the target volume using these techniques. Recently, several clinical studies on stereotactic body radiotherapy (SRT) using the 3 D-CRT technique for solitary lung tumors have been reported. The single dose used is 10-15 Gy, and the total sessions are three to five. The local control rate is more than 90% and complication rates are very low. Therefore, this treatment is a promising new non-invasive treatment for early stage lung cancer. A multi-institutional clinical study, JCOG 0403, in now underway.
三维适形放疗（3D-CRT）技术和患者固定技术最近得到了发展，使我们能够在相对较少照射正常组织的情况下，将高剂量聚焦于靶区。在孤立性肺肿瘤的放疗中，使用这些技术仅在靶区给予更高剂量，可安全地提高局部控制率。最近，已有多项关于使用3D-CRT技术对孤立性肺肿瘤进行立体定向体部放疗（SRT）的临床研究报道。单次剂量为10-15Gy，总疗程为三至五次。局部控制率超过90%，并发症发生率很低。因此，这种治疗方法是早期肺癌一种有前景的新型非侵入性治疗手段。一项多机构临床研究JCOG 0403正在进行中。
