Rowe Sarah K, Rapaport Mark Hyman
Cedars-Sinai Medical Center, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90048, USA.
Curr Opin Psychiatry. 2006 Jan;19(1):9-13. doi: 10.1097/01.yco.0000194148.26766.ba.
The purpose of this review is to evaluate the recent literature on depressive spectrum disorders.
Research into so-called 'minor' forms of depression has moved beyond efforts justifying these entities and describing their components to an exploration of the impact of depressive spectrum disorders on health, quality of life, and as a predisposing factor for major depressive disorder. As with major depression, pharmacological and psychosocial interventions may be useful treatments. Researchers have begun to examine the nature of depressive spectrum disorders in specific populations, such as the elderly and the medically ill.
Sub-threshold forms of depression are becoming a focus of research at a time when quality of life and prevention of serious mental illness are being recognized as important public health concerns. Individuals with depressive spectrum disorders are at an increased risk of developing major depressive disorder and are more likely to have a history of episodes of depression. The challenges confronting psychiatric researchers include developing a consensus about diagnosis of depressive spectrum disorders and ways to measure their severity, and increasing public recognition of the impact of the entire spectrum of depression in order to facilitate the discovery of appropriate treatments.
本综述旨在评估近期关于抑郁谱系障碍的文献。
对所谓“轻度”抑郁形式的研究已从证明这些实体的存在并描述其组成部分,转向探索抑郁谱系障碍对健康、生活质量的影响,以及作为重度抑郁症的诱发因素。与重度抑郁症一样,药物和心理社会干预可能是有效的治疗方法。研究人员已开始研究特定人群(如老年人和患有内科疾病者)中抑郁谱系障碍的本质。
在生活质量和预防严重精神疾病被视为重要公共卫生问题之际,亚阈值抑郁形式正成为研究焦点。患有抑郁谱系障碍的个体患重度抑郁症的风险增加,且更可能有抑郁症发作史。精神病学研究人员面临的挑战包括就抑郁谱系障碍的诊断及测量其严重程度的方法达成共识,以及提高公众对整个抑郁谱系影响的认识,以便促进发现合适的治疗方法。