Massie Charles, Mills Ian G
CRUK Uro-Oncology Group, Department of Oncology, University of Cambridge, c/o Hutchison/MRC Cancer Research Centre, Addenbrookes Hospital, Hills Road, Cambridge, CB2 2XZ, UK.
Nat Rev Cancer. 2006 May;6(5):403-9. doi: 10.1038/nrc1882.
The response of a cell to the myriad of signals that it receives is varied, and it is dependent on many different factors. The most-studied responses involve growth-factor signalling and these signalling cascades have become key targets for cancer therapy. Recent reports have indicated that growth-factor receptors and associated adaptors can accumulate in the nucleus. Are there novel functions for these proteins that might affect our understanding of their role in cancer and have implications for drug resistance?
细胞对其接收到的无数信号的反应各不相同，且取决于许多不同因素。研究最多的反应涉及生长因子信号传导，这些信号级联反应已成为癌症治疗的关键靶点。最近的报告表明，生长因子受体和相关衔接蛋白可在细胞核中积累。这些蛋白质是否具有新功能，可能会影响我们对其在癌症中作用的理解，并对耐药性产生影响？
