Jacobsen P K, Tarnow L, Parving H-H
Steno Diabetes Center, Gentofte, Denmark.
Kidney Int. 2006 Apr;69(8):1293-5. doi: 10.1038/sj.ki.5000283.
One reason for the inadequacy of current renoprotective therapy and the persistent poor renal prognosis in diabetic nephropathy is the large interindividual variation in response to treatment. Genetic as well as non-genetic factors are known to influence treatment efficacy. This Commentary summarizes the impact of the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism in the ACE gene on initiation and progression of diabetic nephropathy.
当前肾脏保护治疗效果不佳以及糖尿病肾病患者肾脏预后持续较差的一个原因是个体对治疗的反应存在很大差异。已知遗传因素和非遗传因素都会影响治疗效果。本述评总结了血管紧张素转换酶（ACE）基因插入/缺失多态性对糖尿病肾病发生和进展的影响。
