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扁桃体切除术中抗生素的使用:治疗性还是预防性?必要还是过度?

Antibiotic use in tonsillectomies: therapeutic or prophylactic? Required or excessive?

作者信息

Piltcher Otávio Bejzman, Scarton Fabiana Bortoncello

机构信息

Faculdade de Ciências Médicas, Santa Casa de São Paulo.

出版信息

Braz J Otorhinolaryngol. 2005 Sep-Oct;71(5):686-90. doi: 10.1016/s1808-8694(15)31275-1. Epub 2006 Mar 31.

Abstract

Adenotonsillectomy is one of the most commonly performed surgeries in the pediatric and young adult populations. The postoperative morbidity of this surgical procedure is often significant, including odynophagia, dysphagia, fever, halitosis, loss of weight and reduced oral intake. After tonsillectomy, with or without adenoidectomy, the colonization of the open tonsillar fossae by the bacterial population of the oral cavity would cause an exacerbation of the local inflammatory response worsening postoperative pain. The hypothesis that a reduction of the bacterial population of an open surgical wound could minimize the local inflammation, stimulate the healing process and hasten recovery triggered a considerable number of studies addressing the relation between the use of perioperative antibiotics and postoperative morbidity of adenotonsillectomy. In spite of the fact that those studies claim to perform an assessment of the surgical prophylactic use of antibiotics, their outline is not in compliance with the worldwide-accepted principles of surgical antibiotic prophylaxis. By performing a critical review of the literature, the authors discuss the advantages and disadvantages of using antibiotics in tonsillectomies or adenotonsillectomies, as well as the most appropriate definition for its utilization.

摘要

腺样体扁桃体切除术是儿科和年轻成人中最常进行的手术之一。该手术的术后发病率通常较高,包括吞咽痛、吞咽困难、发热、口臭、体重减轻和经口摄入量减少。扁桃体切除术后,无论是否同时进行腺样体切除术,口腔细菌在开放的扁桃体窝内定植都会导致局部炎症反应加剧,使术后疼痛恶化。减少开放性手术伤口细菌数量可将局部炎症降至最低、刺激愈合过程并加速康复这一假设引发了大量关于围手术期使用抗生素与腺样体扁桃体切除术后发病率之间关系的研究。尽管这些研究声称对手术预防性使用抗生素进行了评估,但其概要并不符合全球公认的手术抗生素预防原则。通过对文献进行批判性综述,作者讨论了在扁桃体切除术或腺样体扁桃体切除术中使用抗生素的利弊,以及其使用的最恰当定义。

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本文引用的文献

5
Antibiotic prophylaxis post-tonsillectomy: is it of benefit?
Int J Pediatr Otorhinolaryngol. 1999 Oct 15;50(1):15-22. doi: 10.1016/s0165-5876(99)00228-1.
7
Bacteraemia during tonsillectomy: a study of the factors involved and clinical implications.
Clin Otolaryngol Allied Sci. 1998 Feb;23(1):63-6. doi: 10.1046/j.1365-2273.1998.00082.x.
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Tonsillectomy--some like it hot.
Laryngoscope. 1984 May;94(5 Pt 1):677-9.

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