Laterre P F, Colardyn F, Delmée M, De Waele J, Legrand J C, Van Eldere J, Vergison A, Vogelaers D
Department of Critical Care Medicine, St Luc University Hospital, Brussels, Belgium.
Acta Chir Belg. 2006 Jan-Feb;106(1):2-21. doi: 10.1080/00015458.2006.11679825.
Intra-abdominal infection is a common cause of severe sepsis in a hospital setting and remains associated with a significant morbidity, mortality and resource use. Early adequate surgery or drainage remain the cornerstones of intra-abdominal infection management and impact on patients outcome. Concomitant early and adequate empiric antimicrobial therapy further influences patients morbidity and mortality. Multiple empirical regimens have been proposed in this setting, but rarely supported by well designed, randomized-controlled studies. The current manuscript summarizes the recommendations of the Infection Disease Advisory Board on the management of intra-abdominal infections. Empiric antimicrobial therapy for the most common causes of abdominal infections is proposed. In addition, particular attention has been paid on antibiotic treatment duration.
腹腔内感染是医院环境中严重脓毒症的常见原因，并且仍然与显著的发病率、死亡率及资源利用相关。早期充分的手术或引流仍然是腹腔内感染管理的基石，并影响患者的预后。同时进行早期且充分的经验性抗菌治疗会进一步影响患者的发病率和死亡率。在这种情况下已经提出了多种经验性治疗方案，但很少有设计良好的随机对照研究予以支持。本手稿总结了感染病咨询委员会关于腹腔内感染管理的建议。文中提出了针对腹部感染最常见病因的经验性抗菌治疗方案。此外，还特别关注了抗生素治疗的持续时间。
