Balkan M, Beyzadeoglu M, Oysul K, Dirican B, Surenkok S, Tufan T
General Surgery Department, Gulhane Military Faculty of Medicine, Ankara, Turkey.
Acta Chir Belg. 2006 Jan-Feb;106(1):73-6. doi: 10.1080/00015458.2006.11679838.
This study was undertaken to assess the effect of intra-operative radiotherapy on intestinal wound healing and prevention of its side effects by retinoic acid.
Thirty Spraque-Dawley rats were divided into 3 groups of (n = 10). All the groups had laparatomies and terminal ileum exteriorization. Group I was the control group with no irradiation and no anastomosis; group II had both irradiation and anastomosis and group III rats had peroral retinoic acid conditioning and irradiation + anastomosis. On the seventh postoperative day, tensile strength and intestinal elongation measurements were to evaluate the effect of retinoic acid on wound healing.
Compared to the non-retinoic acid conditioned group, the retinoic acid conditioned group had statistically significant higher tensile strength and lower intestinal elongation values, revealing better wound healing.
Peroral retinoic acid supplement administration has a preventive effect on radiation-induced wound-healing inhibition in intra-operative abdominopelvic irradiation and anastomoses.
本研究旨在评估术中放疗对肠道伤口愈合的影响以及视黄酸对其副作用的预防作用。
将30只Spraque-Dawley大鼠分为3组（每组n = 10）。所有组均进行剖腹手术并将回肠末端外置。第一组为对照组，不进行照射和吻合；第二组进行照射和吻合，第三组大鼠进行口服视黄酸预处理以及照射+吻合。术后第7天，通过测量拉伸强度和肠管伸长来评估视黄酸对伤口愈合的影响。
与未用视黄酸预处理的组相比，用视黄酸预处理的组拉伸强度在统计学上显著更高，肠管伸长值更低，表明伤口愈合更好。
口服补充视黄酸对术中腹盆腔照射及吻合时辐射诱导的伤口愈合抑制具有预防作用。
