Vinokurova L V, Zhivaeva N S, Tsaregorodtseva T M, Serova T I
Ter Arkh. 2006;78(2):57-60.
To determine characteristics of a cytokine status in chronic pancreatitis (CP) depending on etiological factor, stage of the disease, complications, therapy. Material and methods. 72 patients had chronic alcoholic pancreatitis (CAP), 38 patients--chronic biliary pancreatitis (CBP). Control group consisted of 20 healthy subjects.
At early stages and height of CAP exacerbation, concentrations of IL-1beta, IL-6, IL-8, TNF-gamma and TNFalpha were elevated (951.1 +/- 104.2 pg/ml; 172.8 +/- 24.3 pg/ml; 432.6 +/- 68.5 pg/ml; 823.3 +/- 97.5 pg/ml; 158.7 +/- 19.6 pg/ml, respectively). Regenerative processes in CP were accompanied with IL-4 elevation to 614.9 +/- 64.6 pg/ml. In CAP without complications and with them the levels of cytokines differed significantly. The level of TGF-beta1 stimulating development of fibrosis was in CAP patients 627.8 +/- 92.2 pg/ml, in CAP patients with complications--796.8 +/- 102.5, in the controls--40.2 +/- 4.6 pg/ml (p < 0.05). In early stages of CBP exacerbation, IL-1beta rose to 527.2 +/- 62.7 pg/ml, IL-6--to 80.9 +/- 11.4 pg/ml, IL-8--to 290.4 +/- 46.8 pg/ml, INF-gamma to 853.3 +/- 91.6 pg/ml; TNF-alpha--to 79.7 +/- 8.3 pg/ml, TGF-beta1--534.1 +/- 78.4 pg/ml. With attenuation of acute syndromes and development ofregeneration, levels of IL-4 went up (226.7 +/- 32.4 pg/ml).
CP is accompanied by increase in cytokine contents depending on the etiological factor, variants of course, stage, presence of complications.
根据病因、疾病阶段、并发症及治疗情况，确定慢性胰腺炎（CP）患者的细胞因子状态特征。材料与方法。72例患者患有慢性酒精性胰腺炎（CAP），38例患者患有慢性胆源性胰腺炎（CBP）。对照组由20名健康受试者组成。
在CAP加重的早期和高峰期，IL-1β、IL-6、IL-8、TNF-γ和TNFα的浓度升高（分别为951.1±104.2 pg/ml；172.8±24.3 pg/ml；432.6±68.5 pg/ml；823.3±97.5 pg/ml；158.7±19.6 pg/ml）。CP中的再生过程伴随着IL-4升高至614.9±64.6 pg/ml。在无并发症和有并发症的CAP中，细胞因子水平有显著差异。刺激纤维化发展的TGF-β1水平在CAP患者中为627.8±92.2 pg/ml，在有并发症的CAP患者中为796.8±102.5 pg/ml，在对照组中为40.2±4.6 pg/ml（p<0.05）。在CBP加重的早期，IL-1β升至527.2±62.7 pg/ml，IL-6升至80.9±11.4 pg/ml，IL-8升至290.4±46.8 pg/ml，INF-γ升至853.3±91.6 pg/ml；TNF-α升至79.7±8.3 pg/ml，TGF-β1为534.1±78.4 pg/ml。随着急性综合征的缓解和再生的发展，IL-4水平升高（226.7±32.4 pg/ml）。
CP伴随着细胞因子含量的增加，这取决于病因、病程、阶段及并发症的存在情况。
