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[避免人工假体与患者不匹配]

[Avoidance of patient-prosthesis mismatch].

作者信息

Sakamoto Y, Hashimoto K

机构信息

Department of Cardiovascular Surgery, the Jikei University School of Medicine, Tokyo, Japan.

出版信息

Kyobu Geka. 2006 Apr;59(4):262-8.

PMID:16613142
Abstract

To minimize the incidence of patient-prosthesis mismatch (PPM), we have routinely adopted aortic root enlargement to avoid PPM for patients with small aortic annulus. The aim of this study was to review our strategy of avoiding PPM. The Carpentier-Edwards Perimount (CEP) valves were implanted in 53 patients who were mostly aged over 65 and the St. Jude Medical (SJM) mechanical valves were used in 128 patients aged under 65. A standard 21-mm SJM valve was used in only 3 patients and no 19-mm valves were employed. However, 19-mm CEP valves were used in 12 patients with a small body surface area (1.43 +/- 0.14 m2). Of these, 26 patients (14.4%) who had a small aortic annulus and 24 patients aged under 65 underwent aortic root enlargement. No patient receiving an SJM valve had an projected indexed effective orifice area (EOAI) < or = 0.85 cm2/m2 because of performing aortic valve replacement (AVR) with annular enlargement and only 2 (3.8%) out of 53 patients receiving CEP valves developed PPM. Consequently, the prevalence of PPM was 1.1% in this series. The prevalence of PPM was low in patients over 65 years old with a relatively small body size who received bioprosthetic valves. A pericardial bioprosthesis was considered to be an appropriate valve in older population with regard to avoiding PPM. In patients under 65 years old with a small annulus, the first choice for avoiding PPM is aortic annular enlargement, which may be avoided by high performance mechanical valves with larger EOA.

摘要

为使人工瓣膜与患者不匹配(PPM)的发生率降至最低,我们常规采用主动脉根部扩大术,以避免主动脉瓣环较小患者出现PPM。本研究的目的是回顾我们避免PPM的策略。53例患者植入了Carpentier-Edwards Perimount(CEP)瓣膜,这些患者大多年龄超过65岁,128例65岁以下患者使用了圣犹达医疗(SJM)机械瓣膜。仅3例患者使用了标准的21毫米SJM瓣膜,未使用19毫米瓣膜。然而,12例体表面积较小(1.43±0.14平方米)的患者使用了19毫米CEP瓣膜。其中,26例(14.4%)主动脉瓣环较小的患者和24例65岁以下患者接受了主动脉根部扩大术。接受SJM瓣膜的患者中,由于进行了带瓣环扩大的主动脉瓣置换术(AVR),没有患者的预计指数有效瓣口面积(EOAI)≤0.85平方厘米/平方米,接受CEP瓣膜的53例患者中只有2例(3.8%)发生了PPM。因此,本系列中PPM的发生率为1.1%。接受生物瓣膜的65岁以上、体型相对较小的患者中PPM的发生率较低。就避免PPM而言,心包生物瓣膜被认为是老年人群中合适的瓣膜。对于65岁以下、瓣环较小的患者,避免PPM的首选方法是主动脉瓣环扩大术,这可以通过具有较大EOA的高性能机械瓣膜来避免。

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