Sato Yuichi, Saito Satoshi, Takahashi Motoichiro
Department of Cardiology, Nihon University School of Medicine.
Nihon Rinsho. 2006 Apr;64(4):677-85.
Recent pathological and clinical observations support the notion that coronary artery plaque disruption and subsequent thrombosis is the primary cause of acute coronary syndrome (ACS) including acute myocardial infarction and unstable angina. Therefore, detection and characterization of coronary artery plaques are of utmost importance in the management of patients with suspected coronary artery disease. Histologic and clinical observations using intravascular ultrasound have suggested that vulnerable, rupture-prone plaques are characterized by the presence of large lipid cores, thin fibrous caps and positive coronary artery remodeling. In this review, we describe the efficacy of multislice computed tomography (MSCT) to characterize vulnerable plaques, especially in patients with suspected ACS. In addition, the efficacy of coronary magnetic resonance imaging is discussed.
冠状动脉斑块破裂及随后的血栓形成是包括急性心肌梗死和不稳定型心绞痛在内的急性冠状动脉综合征(ACS)的主要病因。因此,冠状动脉斑块的检测和特征描述在疑似冠状动脉疾病患者的管理中至关重要。使用血管内超声的组织学和临床观察表明,易损、易破裂斑块的特征是存在大的脂质核心、薄的纤维帽以及冠状动脉正性重构。在本综述中,我们描述了多层螺旋计算机断层扫描(MSCT)在特征化易损斑块方面的效能,尤其是在疑似ACS患者中。此外,还讨论了冠状动脉磁共振成像的效能。