Fukuda Daiju, Sata Masataka
Department of Cardiovascular Medicine, University of Tokyo.
Nihon Rinsho. 2006 Apr;64(4):805-9.
The renin-angiotensin system(RAS) has been demonstrated to play a critical role in initiation and progression of atherosclerosis, thereby contributing to development cardiovascular diseases. Angiotensin II(Ang II), major substrate in RAS, stimulates atherosclerosis through various processes such as endothelial dysfunction, cellular proliferation and inflammation. Recently, local RAS in vasculature is reported to play an important role. Many of these atherogenic effects of Ang II are mediated by reactive oxygen species(ROS). Investigation of the role of ROS and inflammation induced by RAS may provide a clue to understanding the pathophysiology of atherosclerotic diseases, and may lead to a new therapeutic strategy.
肾素-血管紧张素系统（RAS）已被证明在动脉粥样硬化的发生和发展中起关键作用，从而导致心血管疾病的发生。血管紧张素II（Ang II）是RAS中的主要底物，通过内皮功能障碍、细胞增殖和炎症等多种过程刺激动脉粥样硬化。最近，有报道称血管中的局部RAS起重要作用。Ang II的许多致动脉粥样硬化作用是由活性氧（ROS）介导的。研究RAS诱导的ROS和炎症的作用可能为理解动脉粥样硬化疾病的病理生理学提供线索，并可能导致新的治疗策略。
