Luo He-Chun, Qian Rui-Qin, Zhao Xue-Ying, Bi Juan, Xin Hongling, Jiang Xuezhu, Xu Ke, Yan Shaoxiao
Department of Integrative Chinese and Western Medicine, The Sixth Hospital Affiliated to Beijing University, Beijing (100083).
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Mar;26(3):212-4.
To observe the effect and side effect of Danzhi Xiaoyao powder (DXP) in treating depression.
A randomized controlled and double-blinded study was conducted in 63 cases of depression by divided them into the western medicine group (WMG, 31 cases) treated with maprotiline, and the Chinese medicine group (CMG, 32 cases) treated with DXP. The effect of therapy was evaluated before and at the 2nd, 4th and 6th week of the treatment with Hamilton's depressive scale (HAMD), self-rating depression scale (SDS), self-rating anxiety scale (SAS) and the scale for TCM syndrome and symptom differentiation (TCM-SSD), and the side-effect of therapy was assessed with Asberg side-effect scale as well.
There was no significant difference between the two groups in scores of HAMD, SDS, SAS, and TCM-SSD. The markedly effective rate in CMG was 84% and in WMG 87%, showed no significance between them (P > 0.05). The scores of HAMD, SDS and SAS of both groups were remarkably lowered after therapy (P < 0.05). However, the score of Asberg in CMG was lower than that in WMG (P < 0.05).
DXP shows the effect equivalent to that of maprotiline, but with obviously less side-effect.
观察丹栀逍遥散治疗抑郁症的疗效及副作用。
采用随机对照双盲研究方法，将63例抑郁症患者分为西药组（31例），给予麦普替林治疗；中药组（32例），给予丹栀逍遥散治疗。于治疗前及治疗第2、4、6周采用汉密尔顿抑郁量表（HAMD）、自评抑郁量表（SDS）、自评焦虑量表（SAS）及中医证候症状评分量表（TCM-SSD）评定疗效，采用阿斯伯格副作用量表评定副作用。
两组HAMD、SDS、SAS及TCM-SSD评分比较，差异无统计学意义。中药组显效率为84%，西药组为87%，两组比较差异无统计学意义（P＞0.05）。两组治疗后HAMD、SDS及SAS评分均显著降低（P＜0.05）。但中药组阿斯伯格评分低于西药组（P＜0.05）。
丹栀逍遥散治疗抑郁症疗效与麦普替林相当，但副作用明显较少。
