Wu Xian-Ping, Feng Jun-Guang, Chen Hao-Ming, Cheng Fang, Zhang Lipei, Wei Zhijun, Chen Weicai
Hospital of Integrated Traditional and Western Medicine of Foshan City, Guangdong 4 528333.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Mar;26(3):255-7.
To investigate the protective effects of puerarin against myocardial injury in patients with hypertension during perioperational period.
Thirty-four patients with hypertension underwent general anesthesia were randomly divided into the control group and the puerarin group, 500mg puerarin was given to the puerarin group 1hr before anesthesia induction by venoclysis and to the control group, normal saline was given instead. The concentration of serum cardiac troponin I (cTnI) and isoenzyme of creatine kinase containing M and B subunits (CK-MB) were measured before anesthesia induction and 2 hrs after operation respectively.
The serum concentration of cTnI and CK-MB were insignificantly different in the two groups before induction, the two indexes increased in different degrees (P <0.01) 2 hrs after operation in both groups, but the increments in the puerarin group were significantly lower than those in the control group (P< 0.01).
Stress of operation and anesthesia could induce myocardial injury in patients with hypertension, which can be prevented by puerarin medicated during perioperational period.
探讨葛根素对高血压患者围手术期心肌损伤的保护作用。
34例接受全身麻醉的高血压患者随机分为对照组和葛根素组，葛根素组在麻醉诱导前1小时通过静脉滴注给予500mg葛根素，对照组给予等量生理盐水。分别于麻醉诱导前及术后2小时测定血清心肌肌钙蛋白I（cTnI）和肌酸激酶同工酶MB（CK-MB）浓度。
两组诱导前血清cTnI和CK-MB浓度差异无统计学意义，两组术后2小时两项指标均有不同程度升高（P<0.01），但葛根素组升高幅度明显低于对照组（P<0.01）。
手术及麻醉应激可导致高血压患者心肌损伤，围手术期应用葛根素可预防这种损伤。
