Chen Xiaoli, Zhao Jin, Salim Sadia, Garcia Fernando U
Department of Pathology and Laboratory Medicine, Drexel University College of Medicine, Philadelphia, PA 19102, USA.
Hum Pathol. 2006 Mar;37(3):345-51. doi: 10.1016/j.humpath.2005.11.011.
Intraprostatic spermatozoa (IS) have been demonstrated in only 2 articles in the literature reporting on postmortem prostates. Intraprostatic spermatozoa have not been previously described in radical prostatectomies. This is the first study that describes the presence of IS in radical prostatectomies with prostatic carcinoma (PC) and its association with atrophy. We examined whole mount sagittal sections from 69 consecutive radical prostatectomy cases for PC. A central section including the seminal vesicle ejaculatory duct urethra complex (SVEDU) from each case was stained with Berg's stain to identify spermatozoa and their location. The extent and the type of atrophy were assessed on the entire prostate by using a grid method. Eighteen cases (26.1%) revealed spermatozoa both in the SVEDU and in the prostate (IS) (group 1). Twenty-two cases (31.9%) showed spermatozoa exclusively in the SVEDU but not in the prostate (group 2). The remaining 29 cases (42.0%) had no spermatozoa in either site. Location of IS was 72.2% peripheral zone, 22.2% central zone, and 5.6% transitional zone. Intraprostatic spermatozoa were frequently seen accompanied by inflammatory infiltrate in the periglandular stroma. The extent of atrophy was greater in group 1 than in group 2 (25.7% versus 15.3%; P = .006). Postatrophic hyperplasia was seen more frequently in group 1 than in group 2 (72.2% versus 40.9%; P = .025). In conclusion, the frequency of IS is 26.1% when including all prostates and 45.0% when including prostates with evidence of residual ejaculate (spermatozoa in the SVEDU), more than previously reported. Intraprostatic spermatozoa are predominantly located in the peripheral zone similar to atrophy and PC. Prostates with IS have larger atrophic areas and increased frequency of postatrophic hyperplasia. The role of IS in the pathogenesis of prostate inflammation and atrophy should be investigated.
前列腺内精子（IS）仅在2篇关于尸检前列腺的文献中被提及。在前列腺根治术中，此前尚未描述过前列腺内精子的情况。这是第一项描述前列腺癌（PC）根治术中IS的存在及其与萎缩关系的研究。我们检查了69例连续前列腺癌根治术病例的全层矢状切片。对每个病例包括精囊射精管尿道复合体（SVEDU）的中央切片用伯格染色法进行染色，以识别精子及其位置。通过网格法评估整个前列腺的萎缩程度和类型。18例（26.1%）在SVEDU和前列腺中均发现精子（IS）（第1组）。22例（31.9%）仅在SVEDU中发现精子，而在前列腺中未发现（第2组）。其余29例（42.0%）在两个部位均未发现精子。IS的位置为外周区72.2%、中央区22.2%、移行区5.6%。前列腺内精子常伴有腺周基质的炎性浸润。第1组的萎缩程度大于第2组（25.7%对15.3%；P = 0.006）。第1组萎缩后增生的发生率高于第2组（72.2%对40.9%；P = 0.025）。总之，包括所有前列腺时IS的发生率为26.1%，包括有残留射精证据（SVEDU中有精子）的前列腺时为45.0%，高于此前报道。前列腺内精子主要位于外周区，与萎缩和PC相似。有IS的前列腺萎缩面积更大，萎缩后增生的发生率更高。应研究IS在前列腺炎症和萎缩发病机制中的作用。
