Orecchia Roberto, Luini Alberto, Veronesi Paolo, Ciocca Mario, Franzetti Silvia, Gatti Giovanni, Veronesi U
University of Milan, Radiation Oncology Department, European Institute of Oncology, Via Ripamonti 435 I-20141 Milan, Italy.
Expert Rev Anticancer Ther. 2006 Apr;6(4):605-11. doi: 10.1586/14737140.6.4.605.
Intraoperative radiotherapy is a technique where a high, single-fraction radiation dose is delivered directly to the tumor bed during a surgical procedure, after the removal of a neoplastic mass, with minimal exposure of surroundings tissues, which are displaced and shielded during the procedure. Intraoperative radiotherapy has been used in the treatment of various malignancies, mostly in combination with external beam radiation therapy. The long-term results suggest a positive impact on local controls that appear to be associated with increased survival. Modern intraoperative radiotherapy can be performed either with electron beams or photons, and has been used recently in early-stage cancer as a boost or as an exclusive treatment, especially for breast tumors, with extremely promising results. The results of different clinical studies have demonstrated the feasibility of the technique and it is expected that its application will become more widespread in the immediate future. Intraoperative electron radiotherapy in the treatment of initial-stage breast cancer may be an excellent alternative to external beam radiation therapy in an appropriate selected group of patients. However, intensive long-term follow-up is required for a better evaluation of local control and possible side effects.
术中放疗是一种在外科手术过程中，在切除肿瘤块后，将高剂量单次分割的辐射直接施加到肿瘤床的技术，在此过程中周围组织暴露极少，这些组织在手术过程中被移位并得到屏蔽。术中放疗已用于治疗各种恶性肿瘤，大多与外照射放疗联合使用。长期结果表明，其对局部控制有积极影响，这似乎与生存率提高相关。现代术中放疗可使用电子束或光子进行，最近已用于早期癌症，作为一种强化治疗或唯一治疗手段，尤其是对乳腺肿瘤，取得了极有前景的结果。不同临床研究的结果已证明该技术的可行性，预计在不久的将来其应用将更加广泛。对于合适选择的一组患者，术中电子放疗治疗早期乳腺癌可能是外照射放疗的极佳替代方案。然而，需要进行深入的长期随访，以更好地评估局部控制情况和可能的副作用。
