Coutrakon G, Bauman M, Lesyna D, Miller D, Nusbaum J, Slater J, Johanning J, Miranda J, DeLuca P M, Siebers J
Loma Linda University Medical Center, California 92354.
Med Phys. 1991 Nov-Dec;18(6):1093-9. doi: 10.1118/1.596617.
A variable energy proton accelerator was commissioned at Fermi National Accelerator Laboratory for use in cancer treatment at the Loma Linda University Medical Center. The advantages of precise dose localization by proton therapy, while sparing nearby healthy tissue, are well documented [R. R. Wilson, Radiology 47, 487 (1946); M. Wagner, Med. Phys. 9, 749 (1982); M. Goitein and F. Chen, Med. Phys. 10, 831 (1983)]. One of the components of the proton therapy facility is a beam delivery system capable of delivering precise dose distributions to the target volume in the patient. To this end, a prototype beam delivery system was tested during the accelerator's commissioning period. The beam delivery system consisted of a beam spreading device to produce a large, uniform field, a range modulator to generate a spread out Bragg peak (SOBP), and various beam detectors to measure intensity, beam centering, and dose distributions. The beam delivery system provided a uniform proton dose distribution in a cylindrical volume of 20-cm-diam area and 9-cm depth. The dose variations throughout the target volume were found to be less than +/- 5%. Modifications in the range modulator should reduce this considerably. The central axis dose rate in the region of the SOBP was found to be 0.4 cGy/spill with an incident beam intensity of 6.7 x 10(9) protons/spill. With an accelerator repetition rate of 30 spills/min and expected intensity of 2.5 x 10(10) protons/spill for patient treatment, this system can provide 50 cGy/min for a 20-cm-diam field and 9-cm range modulation.(ABSTRACT TRUNCATED AT 250 WORDS)
一台可变能量质子加速器在费米国家加速器实验室投入使用,用于洛马林达大学医学中心的癌症治疗。质子治疗能够精确地定位剂量,同时使附近的健康组织免受辐射,其优势已有充分的文献记载[R. R. 威尔逊,《放射学》47卷,487页(1946年);M. 瓦格纳,《医学物理》9卷,749页(1982年);M. 戈伊坦和F. 陈,《医学物理》10卷,831页(1983年)]。质子治疗设备的组件之一是束流传输系统,它能够向患者体内的目标体积输送精确的剂量分布。为此,在加速器调试期间对一个束流传输系统原型进行了测试。束流传输系统包括一个用于产生大的均匀场的束流扩展装置、一个用于生成扩展布拉格峰(SOBP)的射程调制器以及各种用于测量强度、束流中心和剂量分布的束流探测器。束流传输系统在直径20厘米、深度9厘米的圆柱形体积内提供了均匀的质子剂量分布。发现在整个目标体积内剂量变化小于±5%。射程调制器的改进应能大幅降低这一数值。在SOBP区域的中心轴剂量率在入射束流强度为6.7×10⁹质子/次时为0.4厘戈瑞/次。对于患者治疗,加速器重复率为30次/分钟,预期束流强度为2.5×10¹⁰质子/次,该系统对于直径20厘米的射野和9厘米的射程调制可提供50厘戈瑞/分钟。(摘要截选至250词)