Hendrych J
Ortopedické Oddelení, Krajská Nemocnice Liberec.
Acta Chir Orthop Traumatol Cech. 2006;73(1):34-8.
The aim of the study was to show advantages of post-operative collection of shed blood and its return to the patient's circulation, using blood-reinfusion sets, in terms of requirements for homologous blood, transmission of infections and posttransfusion reactions in total knee arthroplasty.
Two groups of patients were studied. In group 1, comprising 88 patients, shed blood was collected by means of sets for post-operative wound drainage and subsequent autotransfusion. In group 2, with 44 patients, the standard Redon drainage system was used and blood losses were compensated for by homologous blood. Osteoarthrosis of the knee joint was the indication for total knee arthroplasty. Patients with a hemoglobin level lower than 110 g/l, rheumatoid arthropathy, hemophilic arthropathy, coagulopathy, infectious or cancer diseases, or liver or kidney failure were not included, as well as patients who were treated with non-steroid anti-rheumatic drugs, steroids or anticoagulation drugs.
Post-operative blood losses within 6 h of surgery, by 24:00 hours on the day of operation and on the 1st and 2nd postoperative days were recorded. The amount of returned blood and requirements for homologous blood transfusion were also recorded. None of the patients had donated autologous blood. The patients were examined for blood pressure and heart rate; their body temperature was taken, blood samples were collected for blood cell counts and ion (Na(+), K(+), C1(-)) assessment, and urine samples were collected for laboratory tests. All side-effects and complications during hospitalization were recorded as well as all late consequences. The drainage systems used included Redyrob CAT, Retrans and Bellovac ABT.
In group 1, the median value for total post-operative blood loss was 1065 ml, with the median reinfusion value of 500 ml; 31 % of the patients required homologous blood transfusion. In 36 % of the patients, body temperature increased by more than 1 degrees C, as compared with the value before reinfusion, by 24:00 hours on the operative day, and in 2 % it was higher than 38.5 degrees C. No infection occurred in the early post-operative period, but late infectious complications resulted in reimplantation in one patient (1 %). In group 2, the median value of post-operative blood loss was 1045 ml and all patients received homologous blood transfusion. Post-operative complications directly related to blood reinfusion, such as febrile reaction, shivering, pruritus, blood pressure or heart rate fluctuation, renal failure or coagulopathy, were not recorded in either group.
The use of drainage system allowed us to reduce the need for homologous blood transfusion by 63 %. Blood salvage reported in the relevant literature varies between 8 and 80 %, which reflects differences in views on lost blood compensation. The total blood loss in both our groups was in agreement with the data reported by other authors, and the same held true for the reinfusion volume; most of the authors recommend to use a maximum of 800 ml. A higher blood volume carries risks due to a high level of free hemoglobin. The recommended period of 6 h for blood reinfusion was respected (to eliminate potential complement activation). We assume that the temperature higher than 38.5 degrees C found in 2 % of our patients was caused by a changed environment and post-operation reactions. The slightly higher losses recorded by 24:00 hours in group 1 were caused, in our opinion, by the resetting of suction pressure after reinfusion had finished. This difference in shed blood was eliminated during the following day and the total losses were comparable in both groups.
Our results showed that, in total knee arthroplasty, post-operative collection of shed blood and its reinfusion in the circulation can lower the need for homologous blood transfusion and reduce associated risks. If all conditions are observed, i. e., blood reinfusion within 6 h of surgery and the maximum of returned blood not exceeding 800 ml, the method is a safe way of compensating for blood losses in elective knee surgery.
本研究旨在探讨在全膝关节置换术中,使用血液回输装置术后收集引流血并回输给患者,在同源血需求、感染传播及输血后反应方面的优势。
研究对象分为两组。第1组88例患者,采用术后伤口引流及自体输血装置收集引流血。第2组44例患者,使用标准的雷东引流系统,失血用同源血补充。膝关节骨关节炎是全膝关节置换术的指征。血红蛋白水平低于110g/L、类风湿性关节炎、血友病性关节炎、凝血障碍、感染性或癌症疾病、肝或肾衰竭患者,以及正在接受非甾体类抗风湿药物、类固醇或抗凝药物治疗的患者均被排除。
记录手术6小时内、手术当日24:00时及术后第1天和第2天的术后失血量。记录回输血量及同源输血需求。所有患者均未捐献自体血。检查患者血压和心率;测量体温,采集血样进行血细胞计数及离子(Na⁺、K⁺、Cl⁻)评估,采集尿样进行实验室检测。记录住院期间所有副作用和并发症以及所有远期后果。使用的引流系统包括Redyrob CAT、Retrans和Bellovac ABT。
第1组术后总失血量中位数为1065ml,回输量中位数为500ml;31%的患者需要同源输血。36%的患者在手术当日24:00时体温较回输前升高超过1℃,2%的患者体温高于38.5℃。术后早期无感染发生,但1例患者(1%)出现晚期感染并发症导致再次植入。第2组术后失血量中位数为1045ml,所有患者均接受同源输血。两组均未记录与血液回输直接相关的术后并发症,如发热反应、寒战、瘙痒、血压或心率波动、肾衰竭或凝血障碍。
使用引流系统可使同源输血需求降低63%。相关文献报道的血液回收量在8%至80%之间,这反映了对失血补偿的不同观点。两组的总失血量与其他作者报道的数据一致,回输量也是如此;大多数作者建议最大回输量为800ml。较高的血量因游离血红蛋白水平高而存在风险。遵循了推荐的6小时血液回输时间(以消除潜在的补体激活)。我们认为,2%的患者体温高于38.5℃是由环境变化和术后反应引起的。我们认为,第1组在24:00时记录的失血量略高是由于回输结束后吸力压力重置所致。次日这种引流血差异消失,两组总失血量相当。
我们的结果表明,在全膝关节置换术中,术后收集引流血并回输可降低同源输血需求并减少相关风险。如果遵循所有条件,即手术6小时内进行血液回输且回输血量最大不超过800ml,该方法是择期膝关节手术中补偿失血的安全方法。