Ziaei Saeideh, Bonab Khayyati Motlagh, Kazemnejad Anoshirvan
Faculty of Medical Science, Tarbiat Modarres University, Tehran, IR, Iran.
Hypertens Pregnancy. 2006;25(1):3-10. doi: 10.1080/10641950500543756.
The etiology and pathogenesis of hypertensive disorders complicating pregnancy are poorly understood, and the definition of these disorders is controversial.
In a prospective study, 470 primigravida women between 28 and 32 weeks of pregnancy were evaluated for serum levels of total cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, and triglyceride. Afterward, they were observed for any symptoms of preeclampsia and gestational hypertension until 40 weeks of gestational age. We than compared the serum lipid levels among women with preeclampsia and gestational hypertension with those of matched women with normal pregnancies.
The numbers of patients developing preeclampsia and gestational hypertension were 25 (5.3%) and 32 (6.8%), respectively. At the beginning of the study, the mean values of serum triglyceride levels between women who later experienced preeclampsia or gestational hypertension and those who did not differed significantly (p < 0.0001, p < 0.03).
Although many cases of gestational hypertension represent latent essential hypertension based on the lipid levels, some of these women display true pregnancy-induced hypertension or nonproteinuric preeclampsia.
妊娠高血压疾病的病因和发病机制尚不清楚，且这些疾病的定义存在争议。
在一项前瞻性研究中，对470名妊娠28至32周的初产妇进行了总胆固醇、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）胆固醇以及甘油三酯血清水平的评估。之后，观察她们是否出现子痫前期和妊娠期高血压的任何症状，直至孕40周。然后，我们比较了子痫前期和妊娠期高血压女性与匹配的正常妊娠女性的血脂水平。
发生子痫前期和妊娠期高血压的患者人数分别为25例（5.3%）和32例（6.8%）。在研究开始时，后来发生子痫前期或妊娠期高血压的女性与未发生者之间的血清甘油三酯水平平均值无显著差异（p < 0.0001，p < 0.03）。
尽管基于血脂水平，许多妊娠期高血压病例代表潜在的原发性高血压，但其中一些女性表现为真正的妊娠诱导性高血压或无蛋白尿的子痫前期。
