妊娠期高血压疾病与人类凝血因子XI基因的关联研究。
Study of association between hypertensive disorders of pregnancy and the human coagulation factor XI gene.
作者信息
Sato Ichiro, Nakayama Tomohiro, Maruyama Aya, Furuya Kiyohide, Sato Naoyuki, Mizutani Yoshihiro, Yamamoto Tatsuo
机构信息
Department of Obstetrics and Gynecology, Nihon University School of Medicine, Tokyo, Japan.
出版信息
Hypertens Pregnancy. 2006;25(1):21-31. doi: 10.1080/10641950500543863.
OBJECTIVE
Hypertensive disorders of pregnancy (HDP) are among the most common and serious complications of pregnancy. Persuasive evidence implicaties genetic factors in the genesis of HDP. The aim of the present study was to assess the association between single-nucleotide polymorphisms (SNPs) in the human coagulation factor XI (F11) gene and HDP, by conducting a haplotype-based case-control study.
METHODS
We chose 3 SNPs (rs925453, rs925451, and rs12500151) in the human F11 gene as genetic markers. We then conducted an association study with 77 HDP patients and 154 age-matched non-HDP subjects.
RESULTS
The frequency of rs925453 genotypes significantly differed between the two groups. The frequency of the T-G-G haplotype was significantly higher in the HDP group than in the non-HDP group (p = 0.0002).
CONCLUSIONS
The T allele of rs925453 and the T-G-G haplotype appear to be useful genetic markers of HDP.
目的
妊娠期高血压疾病（HDP）是妊娠最常见且严重的并发症之一。有充分证据表明遗传因素参与了HDP的发病过程。本研究旨在通过开展一项基于单倍型的病例对照研究，评估人类凝血因子XI（F11）基因单核苷酸多态性（SNP）与HDP之间的关联。
方法
我们选取人类F11基因中的3个SNP（rs925453、rs925451和rs12500151）作为遗传标记。随后对77例HDP患者和154例年龄匹配的非HDP受试者进行了关联研究。
结果
两组之间rs925453基因型频率存在显著差异。HDP组中T-G-G单倍型的频率显著高于非HDP组（p = 0.0002）。
结论
rs925453的T等位基因和T-G-G单倍型似乎是HDP有用的遗传标记。
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