Xi Z X, Zhang G L, Bi G, Yang G
Department of Physiology, Hubei Medical College, Wuhan.
Sheng Li Xue Bao. 1991 Aug;43(4):389-93.
It has been reported that morphine or opiate-like substances (OLS) can affect the contents of cyclic AMP and/or cyclic GMP in mammalian brain, but very little is known whether similar effects also occur in spinal cord. Using RIA method, we showed that morphine significantly decreased the content of cyclic AMP in the rat spinal cord in vivo and in vitro and this effect could be completely blocked by naloxone, while the concentration of cyclic GMP in rat spinal cord is unchanged. In view of the present experiment it is suggested that the changes of cyclic AMP in the central nervous system may be partly mediated by the action of morphine.
据报道，吗啡或类阿片物质（OLS）可影响哺乳动物脑中环磷酸腺苷（cAMP）和/或环磷酸鸟苷（cGMP）的含量，但对于脊髓中是否也会出现类似作用却知之甚少。我们采用放射免疫分析（RIA）方法表明，吗啡在体内和体外均可显著降低大鼠脊髓中cAMP的含量，且这种作用可被纳洛酮完全阻断，而大鼠脊髓中cGMP的浓度则无变化。鉴于本实验结果，提示中枢神经系统中cAMP的变化可能部分由吗啡的作用介导。
