Shim Eunsook, Shim Hyeeun, Bae Jinhee, Lee Hansoo, Jeoung Dooil
School of Biological Sciences, College of Natural Sciences, Kangwon National University, 200-701, Chunchon, Republic of Korea.
Biotechnol Lett. 2006 Apr;28(7):515-22. doi: 10.1007/s10529-006-0008-5.
The cancer associated gene (CAGE) is a novel cancer/testis antigen. Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity. Further, peptides of CAGE induced cytolytic T lymphocytes (CTL) activity, and CD8+ T cells pre-sensitized with these peptides displayed cytotoxic effects against cancer cells expressing CAGE. These results suggest that CAGE would be a valuable target for the development of an anti-cancer vaccine.
癌症相关基因（CAGE）是一种新型的癌胚抗原。CAGE的过表达提高了生长速率，促进了细胞运动，并导致活性氧清除效应，同时伴有过氧化氢酶腔的诱导。此外，CAGE肽诱导细胞毒性T淋巴细胞（CTL）活性，用这些肽预致敏的CD8 + T细胞对表达CAGE的癌细胞表现出细胞毒性作用。这些结果表明，CAGE将是开发抗癌疫苗的一个有价值的靶点。
