单光子发射计算机断层扫描测量正常人类脑血流量的数据库：II. 用ARG方法对I-123-IMP研究进行定量分析及部分容积校正的影响

Database of normal human cerebral blood flow measured by SPECT: II. Quantification of I-123-IMP studies with ARG method and effects of partial volume correction.

作者信息

Inoue Kentaro, Ito Hiroshi, Shidahara Miho, Goto Ryoi, Kinomura Shigeo, Sato Kazunori, Taki Yasuyuki, Okada Ken, Kaneta Tomohiro, Fukuda Hiroshi

机构信息

Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.

出版信息

Ann Nucl Med. 2006 Feb;20(2):139-46. doi: 10.1007/BF02985626.

DOI:10.1007/BF02985626

PMID:16615423

Abstract

UNLABELLED

The limited spatial resolution of SPECT causes a partial volume effect (PVE) and can lead to the significant underestimation of regional tracer concentration in the small structures surrounded by a low tracer concentration, such as the cortical gray matter of an atrophied brain. The aim of the present study was to determine, using 123I-IMP and SPECT, normal CBF of elderly subjects with and without PVE correction (PVC), and to determine regional differences in the effect of PVC and their association with the regional tissue fraction of the brain.

METHODS

Quantitative CBF SPECT using 123I-IMP was performed in 33 healthy elderly subjects (18 males, 15 females, 54-74 years old) using the autoradiographic method. We corrected CBF for PVE using segmented MR images, and analyzed quantitative CBF and regional differences in the effect of PVC using tissue fractions of gray matter (GM) and white matter (WM) in regions of interest (ROIs) placed on the cortical and subcortical GM regions and deep WM regions.

RESULTS

The mean CBF in GM-ROIs were 31.7 +/- 6.6 and 41.0 +/- 8.1 ml/100 g/min for males and females, and in WM-ROIs, 18.2 +/- 0.7 and 22.9 +/- 0.8 ml/100 g/min for males and females, respectively. The mean CBF in GM-ROIs after PVC were 50.9 +/- 12.8 and 65.8 +/- 16.1 ml/100 g/min for males and females, respectively. There were statistically significant differences in the effect of PVC among ROIs, but not between genders. The effect of PVC was small in the cerebellum and parahippocampal gyrus, and it was large in the superior frontal gyrus, superior parietal lobule and precentral gyrus.

CONCLUSION

Quantitative CBF in GM recovered significantly, but did not reach values as high as those obtained by invasive methods or in the H2(15)O PET study that used PVC. There were significant regional differences in the effect of PVC, which were considered to result from regional differences in GM tissue fraction, which is more reduced in the frontoparietal regions in the atrophied brain of the elderly.

摘要

未标注

单光子发射计算机断层扫描（SPECT）有限的空间分辨率会导致部分容积效应（PVE），并可能导致在低示踪剂浓度包围的小结构中，如萎缩脑的皮质灰质，区域示踪剂浓度被显著低估。本研究的目的是使用123I-异碘安非他明（123I-IMP）和SPECT确定有和没有PVE校正（PVC）的老年受试者的正常脑血流量（CBF），并确定PVC效果的区域差异及其与脑区域组织分数的关联。

方法

使用放射自显影法对33名健康老年受试者（18名男性，15名女性，54 - 74岁）进行123I-IMP定量CBF SPECT检查。我们使用分割的磁共振成像（MR）图像对CBF进行PVE校正，并使用放置在皮质和皮质下GM区域以及深部WM区域的感兴趣区（ROI）中的灰质（GM）和白质（WM）组织分数分析定量CBF和PVC效果的区域差异。

结果

男性和女性在GM-ROI中的平均CBF分别为31.7±6.6和41.0±8.1 ml/100 g/min，在WM-ROI中，男性和女性分别为18.2±0.7和22.9±0.8 ml/100 g/min。PVC后GM-ROI中的平均CBF男性和女性分别为50.9±12.8和65.8±16.1 ml/100 g/min。ROI之间PVC的效果存在统计学显著差异，但性别之间无差异。PVC在小脑和海马旁回的效果较小，而在额上回、顶上小叶和中央前回的效果较大。