Edoh Dominic, Antwi-Bosaiko Charles, Amuzu Dominic
Zoology Department, University of Ghana, Legon, Accra, Ghana.
Afr Health Sci. 2006 Mar;6(1):51-4. doi: 10.5555/afhs.2006.6.1.51.
Fetal hemoglobin has been implicated in the modulation of sickle cell crisis though it is functional during infancy.
The purpose of this study was to determine the waning time of fetal hemoglobin (HbF) and its persistence in later life.
Ninety infants aged 0-12 months, admitted at hospital, were tested for their HbF levels. Adult patients numbering 690 were also examined for their sickle cell status and a sickle positive patient of SS type with HbF had her family members recruited and their sickle cell types determined.
The results revealed that HbF was highest (98%) at birth, decreasing at 5% per week till 6 months when it wane off. Ten infants aged 6-12 months had HbF persisting at a level of 10% or more. Adult patients examined showed proportions of their sickle cell types as AS forming 51%, AC 20%, SS 19%, and SC 10%. An SS adult patient with mild sickle cell crisis had an ASF father who had no crisis and a mother and brother with AS each who had severe crisis.
These findings suggest that HbF wanes off during infancy but persist in some adults and may modulate crisis in these adults. This has implications in sickle cell management.
胎儿血红蛋白虽在婴儿期起作用，但与镰状细胞危象的调节有关。
本研究旨在确定胎儿血红蛋白（HbF）的消退时间及其在成年后的持续情况。
对90名0至12个月住院婴儿进行HbF水平检测。还对690名成年患者进行镰状细胞状态检查，并招募了一名HbF阳性的SS型镰状细胞病患者的家庭成员，确定他们的镰状细胞类型。
结果显示，HbF在出生时最高（98%），每周下降5%，直至6个月时消退。10名6至12个月大的婴儿HbF持续水平为10%或更高。接受检查的成年患者中，镰状细胞类型比例为：AS型占51%，AC型占20%，SS型占19%，SC型占10%。一名患有轻度镰状细胞危象的SS型成年患者，其父亲为ASF型，无危象，母亲和哥哥为AS型，均患有严重危象。
这些发现表明，HbF在婴儿期消退，但在一些成年人中持续存在，可能调节这些成年人的危象。这对镰状细胞病的治疗有重要意义。
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