镰状细胞贫血从出生后不久到青春期的血液学变化情况。
Changing blood picture in sickle-cell anaemia from shortly after birth to adolescence.
作者信息
Davis L R
出版信息
J Clin Pathol. 1976 Oct;29(10):898-901. doi: 10.1136/jcp.29.10.898.
Abstract
The blood picture of children with sickle-cell anaemia was found to change with age. The changes were most marked in the first year but the mean level of haemoglobin, haemoglobin F, and target cells fell until adolescence, and irreversibly sickled cells rose. Reticulocytes, Howell Jolly bodies, and normablasts altered little after one year. The fall in haemoglobin F suggested a delayed changeover from fetal to adult haemoglobin production. It was concluded that the blood changes in sickle-cell anaemia were progressive throughout childhood.
摘要
研究发现，镰状细胞贫血患儿的血象会随着年龄发生变化。这些变化在第一年最为显著，但血红蛋白、血红蛋白F和靶形细胞的平均水平在青春期前持续下降，而不可逆镰状细胞数量上升。网织红细胞、豪-焦小体和正常幼红细胞在一岁后变化不大。血红蛋白F的下降表明从胎儿血红蛋白向成人血红蛋白的转换延迟。研究得出结论，镰状细胞贫血的血液变化在整个儿童期是渐进性的。
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