奈韦拉平所致的史蒂文斯-约翰逊综合征
Stevens - Johnson syndrome due to nevirapine.
作者信息
Namayanja G K, Nankya J M, Byamugisha J K, Ssali F N, Kityo C M, Rwambuya S D, Mugerwa R D, Mmiro F A, Morrison C S, Salata R A
机构信息
Dept of Obstetrics & Gynaecology, Makerere University Medical School, Kampala-Uganda, Kampala.
出版信息
Afr Health Sci. 2005 Dec;5(4):338-40. doi: 10.5555/afhs.2005.5.4.338.
A 25-year-old HIV-infected woman participating in a study of the effects of hormonal contraception on HIV disease progression was started on antiretroviral therapy-Combivir & Nevirapine (NVP) on May 27, 2004. NVP was 200mg daily initially for two weeks to be increased to 200mg bid thereafter. On day twelve, she presented with a mild skin rash on the trunk, purulent conjunctivitis, pharyngitis and fever. She was treated symptomatically and sent home. The following day she returned with a generalized erythematous eruption. She was admitted to JCRC (Joint Clinical and Research Centre) on June 14 and was diagnosed with Stevens - Johnson syndrome (SJS). Antiretroviral therapy was stopped. By July 05, 2004, she had improved and was discharged. After recovery she was restarted on Combivir and Efavirenz and is subsequently doing well on this regimen.
一名25岁感染HIV的女性参与了一项关于激素避孕对HIV疾病进展影响的研究，于2004年5月27日开始接受抗逆转录病毒治疗——Combivir与奈韦拉平（NVP）。NVP最初每日200mg，持续两周，之后增至每日200mg，每日两次。在第12天，她出现躯干轻度皮疹、脓性结膜炎、咽炎和发热。她接受了对症治疗后被送回家。第二天，她带着全身性红斑疹返回。她于6月14日入住联合临床与研究中心（JCRC），被诊断为史蒂文斯 - 约翰逊综合征（SJS）。抗逆转录病毒治疗被停止。到2004年7月5日，她病情好转并出院。康复后，她重新开始服用Combivir和依非韦伦，随后在该治疗方案下情况良好。
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