Ross Shannon A, Fowler Karen B, Ashrith Guha, Stagno Sergio, Britt William J, Pass Robert F, Boppana Suresh B
Department of Pediatrics, University of Alabama at Birmingham, 35233, USA.
J Pediatr. 2006 Mar;148(3):332-6. doi: 10.1016/j.jpeds.2005.09.003.
To define hearing outcomes in children with congenital cytomegalovirus (CMV) infection born to mothers with non-primary CMV infection.
A cohort of 300 children with congenital CMV infection identified by newborn virologic screening at the University of Alabama Hospital and a private community hospital in which the type of maternal infection could be classified constituted the study population. Maternal infections were categorized by analyzing serum samples. Children were followed prospectively and underwent serial audiologic evaluations.
The frequency of hearing loss was not different between children born to mothers with non-primary infection (10%) and those with primary infection (11%). Significantly more children in the primary infection group had progressive and severe/profound hearing loss compared with children in the non-primary group. The frequency of bilateral, delayed onset, high-frequency, and fluctuating hearing loss was not different between the 2 groups. The mean age of diagnosis of hearing loss was 39 +/- 53 months for children born to mothers with non-primary infection and 13 +/- 21 months for the primary infection group (P = .16).
Maternal preexisting seroimmunity to CMV does not provide complete protection against hearing loss in infants with congenital CMV infection.
确定母亲患有非原发性巨细胞病毒（CMV）感染的先天性CMV感染儿童的听力结局。
在阿拉巴马大学医院和一家私立社区医院通过新生儿病毒学筛查确定的300名先天性CMV感染儿童组成了研究人群，其中母亲感染类型可分类。通过分析血清样本对母亲感染进行分类。对儿童进行前瞻性随访并进行系列听力评估。
母亲患有非原发性感染的儿童与患有原发性感染的儿童之间的听力损失发生率没有差异（分别为10%和11%）。与非原发性感染组的儿童相比，原发性感染组中进行性和重度/极重度听力损失的儿童明显更多。两组之间双侧、迟发性、高频和波动性听力损失的发生率没有差异。母亲患有非原发性感染的儿童听力损失诊断的平均年龄为39±53个月，原发性感染组为13±21个月（P = 0.16）。
母亲对CMV预先存在的血清免疫不能为先天性CMV感染婴儿的听力损失提供完全保护。
