Hser Yih-Ing, Stark Maria Elena, Paredes Alfonso, Huang David, Anglin M Douglas, Rawson Richard
Integrated Substance Abuse Programs, Semel Institute of Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA 90025, USA.
J Subst Abuse Treat. 2006 Apr;30(3):219-26. doi: 10.1016/j.jsat.2005.12.007.
The study examined long-term outcomes (mortality, substance use, mental health, employment, criminal involvement) among a cocaine-dependent sample. This 12-year follow-up study, conducted in 2002-2003, updates information obtained at intake and two face-to-face interviews conducted in 1990-1991 and 1991-1992 among 321 male cocaine-dependent veterans admitted to drug treatment in 1988-1989. At the 2002-2003 follow-up, 28 had died and 266 were interviewed. A mixed model examining the longitudinal relationships demonstrated that treatment was associated with lower levels of cocaine use over the 12-year follow-up period after entry into the index treatment and more stable recovery (i.e., continuously abstinent from cocaine for at least 5 years). Few measures at intake predicted stable recovery at follow-up: only being White (vs. being African American) and having greater confidence in ability to avoid cocaine use in high-risk situations. Individuals achieving stable recovery reported less psychiatric symptoms, criminal involvement, and unemployment during the year prior to the interview. Adverse outcomes were apparent for a significant number of cocaine-dependent users who continued to use cocaine for a long period.
该研究调查了可卡因依赖样本的长期结局(死亡率、物质使用情况、心理健康状况、就业情况、犯罪参与情况)。这项于2002年至2003年进行的为期12年的随访研究,更新了1988年至1989年进入戒毒治疗的321名男性可卡因依赖退伍军人在1990年至1991年及1991年至1992年入院时和两次面对面访谈中获取的信息。在2002年至2003年的随访中,28人已死亡,266人接受了访谈。一个检验纵向关系的混合模型表明,在进入索引治疗后的12年随访期内,治疗与较低水平的可卡因使用以及更稳定的康复(即连续至少5年戒除可卡因)相关。入院时几乎没有指标能预测随访时的稳定康复:只有白人(与非裔美国人相比)以及在高风险情况下对避免使用可卡因的能力更有信心。实现稳定康复的个体在访谈前一年报告的精神症状、犯罪参与情况和失业情况较少。对于大量长期持续使用可卡因的可卡因依赖使用者来说,不良结局很明显。