Sullivan Mark D, Robinson James P
Department of Psychiatry, University of Washington, 1959 Pacific Street, Box 356560, Seattle, WA 98195, USA.
Phys Med Rehabil Clin N Am. 2006 May;17(2):381-400, vi-vii. doi: 10.1016/j.pmr.2005.12.006.
Antidepressants and anticonvulsants have been shown to be efficacious in the treatment of neuropathic pain, chronic headache, and other chronic pain conditions. They may be useful in the treatment of disorders in which central nervous system hypersensitivity con-tributes to pain. They provide valuable alternatives or adjuncts to the use of opioid medications in the treatment of chronic pain. Antidepressants have several potential roles in the treatment of chronic pain in addition to their analgesic effects. Specifically, they effectively address the sleep disturbance, depression, and anxiety that are common in patients with chronic pain.
抗抑郁药和抗惊厥药已被证明在治疗神经性疼痛、慢性头痛及其他慢性疼痛病症方面有效。它们可能有助于治疗中枢神经系统超敏反应导致疼痛的病症。在慢性疼痛治疗中，它们为阿片类药物的使用提供了有价值的替代方案或辅助手段。除了止痛作用外，抗抑郁药在慢性疼痛治疗中还有几个潜在作用。具体而言，它们能有效解决慢性疼痛患者常见的睡眠障碍、抑郁和焦虑问题。
