Kay Polly
UCLA Clinical Research Unit, University of California-Los Angeles, 10945 Le Conte Avenue, PVUB 3360, Los Angeles, CA 90095, USA.
Semin Oncol Nurs. 2006 Feb;22(1 Suppl 1):1-4. doi: 10.1016/j.soncn.2006.01.009.
To review the development of targeted therapies and the biology of relevant therapeutic targets. To analyze the relevance of targeted agents as part of current clinical practice.
Research articles.
Several targeted agents are now available for clinical use. Their mechanisms of action are more specific against tumor cells than traditional cytotoxics. Monotherapy regimens based on targeted agents tend to be better tolerated than chemotherapy, and most combination regimens with targeted agents have proven feasible. Their availability has greatly expanded cancer treatment options, especially for chemorefractory patients.
Nurses involved in the care of patients with cancer can benefit from an increased understanding of targeted therapies, including their mechanisms of action, their efficacy profile, as well as prophylaxis and management of adverse events and administration procedures.
回顾靶向治疗的发展及相关治疗靶点的生物学特性。分析靶向药物作为当前临床实践一部分的相关性。
研究文章。
目前有几种靶向药物可供临床使用。它们的作用机制比传统细胞毒性药物对肿瘤细胞更具特异性。基于靶向药物的单药治疗方案往往比化疗耐受性更好，并且大多数靶向药物联合治疗方案已被证明是可行的。它们的可用性极大地扩展了癌症治疗选择，尤其是对于化疗难治性患者。
参与癌症患者护理的护士可以通过增加对靶向治疗的了解而受益，包括其作用机制、疗效概况以及不良事件的预防和管理及给药程序。
